Prognostic Value of Heart Rate Variability in Patients With Cancer

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dc.contributor.authorGuo, Ying
dc.contributor.authorKoshy, Shalini
dc.contributor.authorHui, David
dc.contributor.authorPalmer, J. Lynn
dc.contributor.authorShin, Ki
dc.contributor.authorBozkurt, Mehtap
dc.contributor.authorYusuf, Syed Wamique
dc.date.accessioned2024-04-24T17:08:36Z
dc.date.available2024-04-24T17:08:36Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction:Previous studies have shown that autonomic dysfunction is associated with shorter survival in patients with advanced cancer. We examined the association between heart rate variability, a measure of autonomic function, and survival in a large cohort of patients with cancer.Methods:We retrospectively examined the records of 651 patients with cancer who had undergone ambulatory electrocardiogram monitoring for 20 to 24 hours. Time domain heart rate variability (SD of normal-to-normal beat interval [SDNN]) was calculated using power spectral analysis. Survival data were compared between patients with SDNN 70 milliseconds (Group 1, n = 520) and SDNN < 70 milliseconds (Group 2, n = 131).Results:Two groups were similar in most variables, except that patients in group 2 had a significantly higher percentage of male patients (P = 0.03), hematological malignancies (P = 0.04), and use of non-selective serotonin reuptake inhibitor antidepressants (P = 0.04). Patients in group 2 had a significantly shorter survival rate (25% of patients in group 2 died by 18.7 weeks vs. 78.9 weeks in group 1 patients; P < 0.0001). Multivariate analysis showed that SDNN < 70 milliseconds remained significant for survival (hazard ratio 1.9 [95% confidence interval: 1.4-2.5]) independent of age, cancer stage, and performance status.Conclusion:The presence of cancer in combination with decreased heart rate variability (SDNN < 70 milliseconds) is associated with shorter survival time.en_US
dc.description.sponsorshipNCI NIH HHS [P30 CA016672] Funding Source: Medlineen_US
dc.identifier.doi10.1097/WNP.0000000000000210
dc.identifier.endpage520en_US
dc.identifier.issn0736-0258
dc.identifier.issn1537-1603
dc.identifier.issue6en_US
dc.identifier.pmid26629761
dc.identifier.scopus2-s2.0-84948986975
dc.identifier.scopusqualityQ2
dc.identifier.startpage516en_US
dc.identifier.urihttps://doi.org/10.1097/WNP.0000000000000210
dc.identifier.urihttps://hdl.handle.net/11468/17397
dc.identifier.volume32en_US
dc.identifier.wosWOS:000365774300014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Clinical Neurophysiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHeart Rate Variabilityen_US
dc.subjectCanceren_US
dc.subjectAutonomic Dysfunctionen_US
dc.subjectSurvivalen_US
dc.subjectPrognosisen_US
dc.titlePrognostic Value of Heart Rate Variability in Patients With Canceren_US
dc.titlePrognostic Value of Heart Rate Variability in Patients With Cancer
dc.typeArticleen_US

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