The effect of low-dose Cordyceps on ischemia-reperfusion of the in rats

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dc.contributor.authorAydogdu, Bahattin
dc.contributor.authorBasuguy, Erol
dc.contributor.authorArslan, Serkan
dc.contributor.authorAzizoglu, Mustafa
dc.contributor.authorIbiloglu, Ibrahim
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorAydogdu, Gulay
dc.date.accessioned2024-04-24T17:20:21Z
dc.date.available2024-04-24T17:20:21Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: None of studies have been conducted in terms of demonstrating the same effect with the low dose in cordycepin. In our study, we analyzed the histopathological and biochemical changes of low-dose Cordycepin(c) on a rat model in the kidney. Materials and methods: Twenty-four male Wistar Albino rats were randomly allocated to three groups (n = 8): the sham-control group (Group 1), the renal I/R-untreated (Group 2) group, and the I/R-C-treated (Group 3) group. Cordyceps was administered intraperitoneally at 5 mg/kg twice. Renal histological changes were compared and the relevant parameters of oxidative stress and inflammation were detected. Results: In blood and tissue biochemistry, it was observed that IL-1 Beta, IL 6, TNF alpha, MDA, TOS, and OSI increased in Group 2 and decreased in Group 3. It was determined that TAS values were increased in Group 3, and decreased in Group 2. In the histopathological evaluation, while Group 1 was evaluated as normal, significant kidney damage was detected in Group 2. It was determined that there was a significant decrease in kidney damage in Group 3. Conclusion: These results suggest that low dose Cordycepin was as effective as normal dose on renal ischemic reperfusion and reduction of damage.en_US
dc.identifier.doi10.24875/CIRU.22000303
dc.identifier.endpage74en_US
dc.identifier.issn0009-7411
dc.identifier.pmid36480757
dc.identifier.scopus2-s2.0-85143565257
dc.identifier.scopusqualityQ3
dc.identifier.startpage69en_US
dc.identifier.urihttps://doi.org/10.24875/CIRU.22000303
dc.identifier.urihttps://hdl.handle.net/11468/18971
dc.identifier.volume90en_US
dc.identifier.wosWOS:000892344900012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMexican Acad Surgeryen_US
dc.relation.ispartofCirugia Y Cirujanos
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCordycepsen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectKidneyen_US
dc.titleThe effect of low-dose Cordyceps on ischemia-reperfusion of the in ratsen_US
dc.titleThe effect of low-dose Cordyceps on ischemia-reperfusion of the in rats
dc.typeArticleen_US

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