Thrombophilia and Recurrent Pregnancy Loss: The Enigma Continues

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dc.contributor.authorBarut, Mert Ula
dc.contributor.authorBozkurt, Murat
dc.contributor.authorKahraman, Mehmet
dc.contributor.authorYildirim, Engin
dc.contributor.authorImirzatioglu, Necat
dc.contributor.authorKubar, Ayhan
dc.contributor.authorSak, Sibel
dc.date.accessioned2024-04-24T17:15:08Z
dc.date.available2024-04-24T17:15:08Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Thrombophilic gene polymorphism is known to be a risk factor for recurrent pregnancy loss (RPL), but few studies have confirmed a possible role of thrombophilic genes polymorphism in RPL risk. This study was conducted to understand the relationship of the mutations of some thrombophilia-associated gene polymorphism (heterozygous/homozygous) with RPL. We compared patients with 2 abortions to patients with 3 or more abortions among Turkish women. Material/Methods: In this study, patients previously diagnosed with habitual abortus at Obstetrics and Gynecology outpatient clinics in Turkey between 2012 and 2016 were included. In their peripheral blood, we detected factor V Leiden H1299R, prothrombin G20210A, MTHFR C677T, MTHFR A1298C, PAI-1 4G/5G, and PAI-1 4G/4G gene mutations. Results: In this study, we have observed statistically meaningful data (P<0.01) related to the relationship between RPL and thrombophilia-associated gene polymorphisms such as heterozygous factor V Leiden H1299R, heterozygous prothrombin G20210A, PAI-1 4G/5G, and PAI-1 4G/4G. Conclusions: We found that diagnosis of thrombophilic genes polymorphism is useful to determine the causes of RPL, recognizing that this multifactorial disease can also be influenced by various acquired factors, including reproduction-associated risk factors and prolonged immobilization.en_US
dc.identifier.doi10.12659/MSM.908832
dc.identifier.endpage4294en_US
dc.identifier.issn1643-3750
dc.identifier.pmid29932168
dc.identifier.scopus2-s2.0-85049663652
dc.identifier.scopusqualityQ1
dc.identifier.startpage4288en_US
dc.identifier.urihttps://doi.org/10.12659/MSM.908832
dc.identifier.urihttps://hdl.handle.net/11468/18347
dc.identifier.volume24en_US
dc.identifier.wosWOS:000436366600002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherInt Scientific Information, Incen_US
dc.relation.ispartofMedical Science Monitor
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAbortion, Habitualen_US
dc.subjectPolymorphism, Geneticen_US
dc.subjectThrombophiliaen_US
dc.titleThrombophilia and Recurrent Pregnancy Loss: The Enigma Continuesen_US
dc.titleThrombophilia and Recurrent Pregnancy Loss: The Enigma Continues
dc.typeArticleen_US

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