A comparison of postoperative complications following cardiac implantable electronic device procedures in patients treated with antithrombotic drugs

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dc.authorid0000-0002-9049-7123en_US
dc.authorid0000-0003-2243-6190en_US
dc.authorid0000-0002-1992-7848en_US
dc.authorid0000-0001-9407-4155en_US
dc.authorid0000-0001-6453-9310en_US
dc.authorid0000-0001-6608-871Xen_US
dc.authorid0000-0001-7317-2979en_US
dc.contributor.authorDemir, Muhammed
dc.contributor.authorÖzbek, Mehmet
dc.contributor.authorPolat, Nihat
dc.contributor.authorAktan, Adem
dc.contributor.authorYıldırım, Bünyamin
dc.contributor.authorArgun, Lokman
dc.contributor.authorİldırımlı, Kamran
dc.contributor.authorToprak, Nizamettin
dc.date.accessioned2023-04-24T13:04:58Z
dc.date.available2023-04-24T13:04:58Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalıen_US
dc.description.abstractBackground The incidence of postoperative complications following cardiac implantable electronic device (CIED) procedures in patients treated with antithrombotic drugs has not been studied sufficiently. Here we present a comparison of complications after CIED implantations. Methods Using an observational study design, the study included 1807 patients with a taking antiplatelet drugs (n: 1601), nonvitamin K anticoagulants (NOAC) (n: 136), and warfarin (n: 70) undergoing CIED surgery. Primary endpoint was accepted as cumulative events including composite of clinically significant hematoma (CSH), pericardial effusion or tamponade, pneumothorax, and infection related to device system. Secondary outcomes included each compenent of cumulative events. Multivariable analysis was performed to identify predictors of cumulative events. Results The overall cumulative event rate was 3.7% (67 of 1807). Cumulative events occured 3.1% (50 of 1601) in the antiplatelet, 5.1% (7 of 136) NOAC, and 14.3% (10 of 70) warfarin groups (p < 0.001). CSH occurred in 2 of 70 patients (2.9%) in the warfarin group, as compared with 5 of 1601 (0.3%) in the antiplatelet group (p: 0.032). However, no significant differences were found between NOAC and warfarin groups in terms of CSH (0.7% vs. 2.9% respectively, p: 0.267). Warfarin treatment was an independent predictor of cumulative events and increased 2.9-fold the risk of cumulative events. Major surgical complications were rare and did not differ significantly between the study groups. Conclusions The incidence and severity of complications may be lower in patients treated with periprocedurally antiplatelet or NOAC therapy when compared with warfarin therapy. Further randomized control studies are required to confirm our findingsen_US
dc.identifier.citationDemir, M., Özbek, M., Polat, N., Aktan, A., Yıldırım, B., Argun, L. ve diğerleri. (2022). A comparison of postoperative complications following cardiac implantable electronic device procedures in patients treated with antithrombotic drugs. Pace-Pacing and Clinical Electrophysiology, 45(6), 733-741.en_US
dc.identifier.doi10.1111/pace.14517
dc.identifier.endpage741en_US
dc.identifier.issn0147-8389
dc.identifier.issn1540-8159
dc.identifier.issue6en_US
dc.identifier.pmid35527396
dc.identifier.scopus2-s2.0-85130277105
dc.identifier.scopusqualityQ3
dc.identifier.startpage733en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1111/pace.14517
dc.identifier.urihttps://hdl.handle.net/11468/11737
dc.identifier.volume45en_US
dc.identifier.wosWOS:000796898900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDemir, Muhammed
dc.institutionauthorÖzbek, Mehmet
dc.institutionauthorPolat, Nihat
dc.institutionauthorYıldırım, Bünyamin
dc.institutionauthorArgun, Lokman
dc.institutionauthorİldırımlı, Kamran
dc.institutionauthorToprak, Nizamettin
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPace-Pacing and Clinical Electrophysiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticoagulantsen_US
dc.subjectBleedingsen_US
dc.subjectComplicationsen_US
dc.subjectPacemakersen_US
dc.subjectPerioperativeen_US
dc.titleA comparison of postoperative complications following cardiac implantable electronic device procedures in patients treated with antithrombotic drugsen_US
dc.titleA comparison of postoperative complications following cardiac implantable electronic device procedures in patients treated with antithrombotic drugs
dc.typeArticleen_US

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