Preventive effects of intracisternal alphatochopherol on cerebral vasospasm in experimental subarachnoid hamorrhage

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dc.contributor.authorKemaloglu, S
dc.contributor.authorÖzkan, U
dc.contributor.authorYilmaz, F
dc.contributor.authorErdem, AK
dc.contributor.authorAcemoglu, H
dc.contributor.authorÖlmez, G
dc.contributor.authorSimsek, R
dc.date.accessioned2024-04-24T17:20:48Z
dc.date.available2024-04-24T17:20:48Z
dc.date.issued2003
dc.departmentDicle Üniversitesien_US
dc.description.abstractVasospasm is an important cause of morbidity and/or mortality with a subarachnoid haemorrhage (SAH). The roles of lipid peroxidation in a vasospasm caused by a SAH remain to be investigated. The effect of an intracisternal administration of alphatochopherol on a cerebral vasospasm was investigated in an experimental model. The authors assessed whether the administration of alpbatochopherol reduced the vasospasm. By means of an intracisternal blood injection model, a SAH was induced in 30 rats, which were randomly divided into three groups, as follows: group I (G1), without a SAH and drug, group II (G2), a SAH alone, group III (G3), a SAH and alphatochopherol. Following the withdrawal of cerebrospinal fluid (CSF), a fresh unheparinized arterial blood was injected into the cisterna magna to induce a SAH. In G3, 20 U (0.4ml) alpbatochopherol was intracisternally injected forty-five hours after induction of the SAH. All rats were sacrificed 72 hours after the induction. The basilar artery, with surrounding tissue, was removed from the cranium. The cross-sectional diameter of the lumen and vessel wall of the rat basilar artery was assessed from a planimetric analysis, and changes compared with G1 and G2. The reduction in the luminal cross-sectional diameter of the vessels exposed to subarachnoid blood was found to be 29.01% (p=0.001). The group treated with alphatochopherol bad a 9% reduction (p=0.004). The role of lipid peroxidation on a vasospasm caused by SAH is well known to be critical. Data from the present study indicated that antioxidant therapy, with topical alphatochopherol, may be promising on a vasospasm caused by a SAH.en_US
dc.identifier.doi10.3349/ymj.2003.44.6.955
dc.identifier.endpage960en_US
dc.identifier.issn0513-5796
dc.identifier.issn1976-2437
dc.identifier.issue6en_US
dc.identifier.pmid14703601
dc.identifier.scopus2-s2.0-18744435555
dc.identifier.scopusqualityQ1
dc.identifier.startpage955en_US
dc.identifier.urihttps://doi.org/10.3349/ymj.2003.44.6.955
dc.identifier.urihttps://hdl.handle.net/11468/19253
dc.identifier.volume44en_US
dc.identifier.wosWOS:000187959500002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherYonsei Univ Coll Medicineen_US
dc.relation.ispartofYonsei Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSubarachnoid Haemorrhageen_US
dc.subjectCerebral Vasospasmen_US
dc.subjectVitamin Een_US
dc.subjectRaten_US
dc.titlePreventive effects of intracisternal alphatochopherol on cerebral vasospasm in experimental subarachnoid hamorrhageen_US
dc.titlePreventive effects of intracisternal alphatochopherol on cerebral vasospasm in experimental subarachnoid hamorrhage
dc.typeArticleen_US

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