The role of basal 18F-FDG PET/CT maximum standard uptake value and maximum standard uptake change in predicting pathological response in breast cancer patients receiving neoadjuvant chemotherapy

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dc.authorid0000-0001-7336-871Xen_US
dc.authorid0000-0001-6990-9683en_US
dc.authorid0000-0003-3878-988Xen_US
dc.authorid0000-0002-7931-2941en_US
dc.authorid0000-0002-7451-7286en_US
dc.contributor.authorAkdeniz, Nadiye
dc.contributor.authorKömek, Halil
dc.contributor.authorKüçüköner, Mehmet
dc.contributor.authorKaplan, Muhammet A.
dc.contributor.authorUrakçı, Zuhat
dc.contributor.authorOruç, Zeynep
dc.contributor.authorIşıkdoğan, Abdurrahman
dc.date.accessioned2022-08-17T12:16:00Z
dc.date.available2022-08-17T12:16:00Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Medikal Onkoloji Ana Bilim Dalıen_US
dc.descriptionWOS:000639298200012
dc.descriptionPMID: 33315727
dc.description.abstractObjective The aim of this study was to determine the role of 18F-FDG PET/CT in predicting pathological response among patients diagnosed with local or locally advanced breast cancer and receiving neoadjuvant chemotherapy (NAC). Methods Basal SUVmax value were analyzed in 212 patients and 142 of these patients had posttreatment SUVmax value. Overall pathological complete response (pCR(C)) was defined as no evidence of residual invasive cancer in breast (pCR(B)) and axilla (pCR(A)). Basal SUVmax value of the breast (SUVmax(B)I) and axilla (SUVmax(A)I) and change in SUVmax of the breast (Delta SUVmax(B)) and axilla (Delta SUVmax(A)) were measured. The optimal cutoff value of SUVmax and Delta SUVmax were determined by receiver operating characteristic curve analysis. Results The number of patients with pCR(B) was 85 (40.1%), pCR(A) was 76 (42.5%) and pCR(C) was 70 (33%). In the artificial neural network-based analysis the Delta SUVmax(B) (100%) was the most important variable for predicting pCR(B). Delta SUVmax(A) (100%) was the most important variable in estimation of pCR(A). When pCR(C) was evaluated, the highest relation was found with Delta SUVmax(B). When the Delta SUVmax(B) cutoff value for pCR(B) and pCR(C) accepted as <=-87.9%, its sensitivity was 82.3 and 82.4%, and specificity was 72.5% and 65.9%, respectively (P < 0.001 and P < 0.001, respectively). When the Delta SUVmax(A) cutoff value for pCR(A) and pCR(C) accepted as <=-86.6%, its sensitivity was 94.3% and 97.6%, and specificity was 31.3% and 28.2%, respectively (P = 0.017 and P = 0.024, respectively). Conclusion Albeit varies according to the molecular subtypes of the breast cancer during NAC, Delta SUVmax value seems to be the most strong factor associated with pCR.en_US
dc.identifier.citationAkdeniz, N., Kömek, H., Küçüköner, M., Kaplan, M.A., Urakçı, Z., Oruç, Z. ve diğerleri. (2021). The role of basal 18F-FDG PET/CT maximum standard uptake value and maximum standard uptake change in predicting pathological response in breast cancer patients receiving neoadjuvant chemotherapy. Nuclear Medicine Communications, 42(3), 315-324. https://doi.org/10.1097/MNM.0000000000001332en_US
dc.identifier.doi10.1097/MNM.0000000000001332
dc.identifier.endpage324en_US
dc.identifier.issn0143-3636
dc.identifier.issn1473-5628
dc.identifier.issue3en_US
dc.identifier.pmid33315727
dc.identifier.scopus2-s2.0-85102090126
dc.identifier.scopusqualityQ3
dc.identifier.startpage315en_US
dc.identifier.urihttps://journals.lww.com/nuclearmedicinecomm/Fulltext/2021/03000/The_role_of_basal_18F_FDG_PET_CT_maximum_standard.12.aspx
dc.identifier.urihttps://hdl.handle.net/11468/10190
dc.identifier.volume42en_US
dc.identifier.wosWOS:000639298200012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKüçüköner, Mehmet
dc.institutionauthorKaplan, Muhammet Ali
dc.institutionauthorUrakçı, Zuhat
dc.institutionauthorOruç, Zeynep
dc.institutionauthorIşıkdoğan, Abdurrahman
dc.language.isoenen_US
dc.publisherLippincott William & Wilkinsen_US
dc.relation.ispartofNuclear Medicine Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectBreast canceren_US
dc.subjectNeoadjuvant chemotherapyen_US
dc.subjectPathological complete responseen_US
dc.subject18F-FDG PET/CTen_US
dc.titleThe role of basal 18F-FDG PET/CT maximum standard uptake value and maximum standard uptake change in predicting pathological response in breast cancer patients receiving neoadjuvant chemotherapyen_US
dc.titleThe role of basal 18F-FDG PET/CT maximum standard uptake value and maximum standard uptake change in predicting pathological response in breast cancer patients receiving neoadjuvant chemotherapy
dc.typeArticleen_US

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