Influence of coumarin and some coumarin derivatives on serum lipid profiles in carbontetrachloride-exposed rats

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dc.contributor.authorTasdemir, Ezel
dc.contributor.authorAtmaca, Mukadder
dc.contributor.authorYildirim, Yasar
dc.contributor.authorBilgin, Hakki Murat
dc.contributor.authorDemirtas, Berjan
dc.contributor.authorObay, Basra Deniz
dc.contributor.authorKelle, Mustafa
dc.date.accessioned2024-04-24T17:14:37Z
dc.date.available2024-04-24T17:14:37Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn the present study, coumarin and some coumarin derivatives (esculetin, scoparone, and 4-methylumbelliferone) were investigated for their lipid-lowering effect in rats. Male Sprague-Dawley rats (150-200 g) were divided into six groups and each group comprised of five rats. Hepatic injury-dependent hyperlipidemia was induced by carbon tetrachloride (CCl4, 1.25 ml/kg). Coumarin and coumarin derivatives esculetin (35 mg/kg), scoparone (35 mg/kg), 4-methylumbelliferone (35 mg/kg), or coumarin (30 mg/kg) were administered to experimental groups at 12-h intervals. Animals received the derivatives esculetin, scoparone or 4-methylumbelliferone prior to the administration of a single toxic dose of CCl4. Serum total cholesterol (TC), triglyceride (TG), very low-density lipoprotein cholesterol (VLDL-C), and low-density lipoprotein cholesterol (LDL-C) levels significantly increased in CCl4-treated group (p < 0.05, p < 0.01, p < 0.01, and p < 0.05, respectively), while levels of serum high-density lipoprotein cholesterol (HDL-C) decreased (p < 0.01). 4-Methylumbelliferone had no recovery effects on serum TC levels, however, significantly prevented CCl4-induced hyperlipidemia by reducing TG and VLDL-C levels (p < 0.05 and p < 0.05, respectively). In addition, coumarin had no recovery effect on any of the serum lipid parameters against CCl4-induced hyperlipidemia. Among the coumarin derivatives only esculetin and scoparone significantly prevented serum HDL-C in CCl4-induced dyslipidemia. The results from this study indicate that the chemical structure of coumarins plays an important role on the regulation of serum lipid profiles.en_US
dc.identifier.doi10.1177/0960327116649675
dc.identifier.endpage301en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue3en_US
dc.identifier.pmid27185181
dc.identifier.scopus2-s2.0-85014469313
dc.identifier.scopusqualityQ2
dc.identifier.startpage295en_US
dc.identifier.urihttps://doi.org/10.1177/0960327116649675
dc.identifier.urihttps://hdl.handle.net/11468/18099
dc.identifier.volume36en_US
dc.identifier.wosWOS:000395408800009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoumarinsen_US
dc.subjectLipiden_US
dc.subjectCcl4en_US
dc.subjectRaten_US
dc.titleInfluence of coumarin and some coumarin derivatives on serum lipid profiles in carbontetrachloride-exposed ratsen_US
dc.titleInfluence of coumarin and some coumarin derivatives on serum lipid profiles in carbontetrachloride-exposed rats
dc.typeArticleen_US

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