Influence of coumarin and some coumarin derivatives on serum lipid profiles in carbontetrachloride-exposed rats
dc.contributor.author | Tasdemir, Ezel | |
dc.contributor.author | Atmaca, Mukadder | |
dc.contributor.author | Yildirim, Yasar | |
dc.contributor.author | Bilgin, Hakki Murat | |
dc.contributor.author | Demirtas, Berjan | |
dc.contributor.author | Obay, Basra Deniz | |
dc.contributor.author | Kelle, Mustafa | |
dc.date.accessioned | 2024-04-24T17:14:37Z | |
dc.date.available | 2024-04-24T17:14:37Z | |
dc.date.issued | 2017 | |
dc.department | Dicle Üniversitesi | en_US |
dc.description.abstract | In the present study, coumarin and some coumarin derivatives (esculetin, scoparone, and 4-methylumbelliferone) were investigated for their lipid-lowering effect in rats. Male Sprague-Dawley rats (150-200 g) were divided into six groups and each group comprised of five rats. Hepatic injury-dependent hyperlipidemia was induced by carbon tetrachloride (CCl4, 1.25 ml/kg). Coumarin and coumarin derivatives esculetin (35 mg/kg), scoparone (35 mg/kg), 4-methylumbelliferone (35 mg/kg), or coumarin (30 mg/kg) were administered to experimental groups at 12-h intervals. Animals received the derivatives esculetin, scoparone or 4-methylumbelliferone prior to the administration of a single toxic dose of CCl4. Serum total cholesterol (TC), triglyceride (TG), very low-density lipoprotein cholesterol (VLDL-C), and low-density lipoprotein cholesterol (LDL-C) levels significantly increased in CCl4-treated group (p < 0.05, p < 0.01, p < 0.01, and p < 0.05, respectively), while levels of serum high-density lipoprotein cholesterol (HDL-C) decreased (p < 0.01). 4-Methylumbelliferone had no recovery effects on serum TC levels, however, significantly prevented CCl4-induced hyperlipidemia by reducing TG and VLDL-C levels (p < 0.05 and p < 0.05, respectively). In addition, coumarin had no recovery effect on any of the serum lipid parameters against CCl4-induced hyperlipidemia. Among the coumarin derivatives only esculetin and scoparone significantly prevented serum HDL-C in CCl4-induced dyslipidemia. The results from this study indicate that the chemical structure of coumarins plays an important role on the regulation of serum lipid profiles. | en_US |
dc.identifier.doi | 10.1177/0960327116649675 | |
dc.identifier.endpage | 301 | en_US |
dc.identifier.issn | 0960-3271 | |
dc.identifier.issn | 1477-0903 | |
dc.identifier.issue | 3 | en_US |
dc.identifier.pmid | 27185181 | |
dc.identifier.scopus | 2-s2.0-85014469313 | |
dc.identifier.scopusquality | Q2 | |
dc.identifier.startpage | 295 | en_US |
dc.identifier.uri | https://doi.org/10.1177/0960327116649675 | |
dc.identifier.uri | https://hdl.handle.net/11468/18099 | |
dc.identifier.volume | 36 | en_US |
dc.identifier.wos | WOS:000395408800009 | |
dc.identifier.wosquality | Q3 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.indekslendigikaynak | PubMed | |
dc.language.iso | en | en_US |
dc.publisher | Sage Publications Ltd | en_US |
dc.relation.ispartof | Human & Experimental Toxicology | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Coumarins | en_US |
dc.subject | Lipid | en_US |
dc.subject | Ccl4 | en_US |
dc.subject | Rat | en_US |
dc.title | Influence of coumarin and some coumarin derivatives on serum lipid profiles in carbontetrachloride-exposed rats | en_US |
dc.title | Influence of coumarin and some coumarin derivatives on serum lipid profiles in carbontetrachloride-exposed rats | |
dc.type | Article | en_US |