The combined effect of rosuvastatin and ischemic pre- or post-conditioning on myocardial ischemia-reperfusion injury in rat heart

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dc.contributor.authorKelle, I.
dc.contributor.authorAkkoc, H.
dc.contributor.authorUyar, E.
dc.contributor.authorErdinc, M.
dc.contributor.authorEvliyaoglu, O.
dc.contributor.authorSaribas, S.
dc.contributor.authorTunik, S.
dc.date.accessioned2024-04-24T17:38:16Z
dc.date.available2024-04-24T17:38:16Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To investigate the combined effect of rosuvastatin and ischemic preconditioning or postconditioning on ischemia-reperfusion injury in in vivo rat heart. MATERIALS AND METHODS: Ninenty-six male adult Wistar rats were randomly assigned to eight groups: Sham group, ischemia-reperfusion, rosuvastatin preconditioning, rosuvastatin postconditioning, ischemic preconditioning, ischemic postconditioning, ischemic + pharmacologic preconditioning and ischemic + pharmacologic postconditioning groups. Blood samples were taken for creatine kinase evaluation at selected time points. Six rats in each group were separated for either infarct size assessment or immunohistochemical staining with Bcl-2 antibody. RESULTS: The staining with Bcl-2 was significantly lower in groups Sham, ischemic + pharmacologic preconditioning and ischemic + pharmacologic postconditioning groups which is well correlated with the decrease in infarct size for the same groups. The creatine kinase enzyme levels were also reduced to their lowest levels in ischemic + pharmacologic preconditioning and ischemic + pharmacologic postconditioning groups. CONCLUSIONS: These findings suggest that enriching the composition of reperfusate with rosuvastatin along with ischemic preconditioning or postconditioning procedures at the opposite sides of ischemia may interact synergistically for protecting ischemic myocardium from reperfusion injury. The combined application of rosuvastatin with ischemic preconditioning or ischemic postconditioning may provide a new therapeutic option in clinical interventions when compared to single treatment with ischemic and rosuvastatin preconditioning or postconditioning.en_US
dc.description.sponsorshipDicle University Research Project Unit [11TF18]en_US
dc.description.sponsorshipThis study was financially supported by the Dicle University Research Project Unit (grant no. 11TF18).en_US
dc.identifier.endpage2476en_US
dc.identifier.issn1128-3602
dc.identifier.issue13en_US
dc.identifier.pmid26214784
dc.identifier.scopus2-s2.0-84942279733
dc.identifier.scopusqualityQ2
dc.identifier.startpage2468en_US
dc.identifier.urihttps://hdl.handle.net/11468/21387
dc.identifier.volume19en_US
dc.identifier.wosWOS:000358613600023
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPreconditioningen_US
dc.subjectPostconditioningen_US
dc.subjectRosuvastatinen_US
dc.subjectReperfusion Injuryen_US
dc.titleThe combined effect of rosuvastatin and ischemic pre- or post-conditioning on myocardial ischemia-reperfusion injury in rat hearten_US
dc.titleThe combined effect of rosuvastatin and ischemic pre- or post-conditioning on myocardial ischemia-reperfusion injury in rat heart
dc.typeArticleen_US

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