Renal effects on a solitary kidney of specific inhibition of cyclooxygenease-2 after 24 h of complete ureteric obstruction in rats

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dc.contributor.authorÖztürk, H
dc.contributor.authorOzdemir, E
dc.contributor.authorOtcu, S
dc.contributor.authorBüyükbayram, H
dc.contributor.authorDokucu, AI
dc.date.accessioned2024-04-24T15:59:50Z
dc.date.available2024-04-24T15:59:50Z
dc.date.issued2002
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe purpose of this study is to show whether selective (celecoxib) and non-selective (piroxicam) inhibitors of COX-2 can alter the morphological and functional changes after the release of a 24 h complete ureteric obstruction in tissue from solitary rat kidney. Forty male Sprague-Dawley rats weighing 225-250 g were used. The animals were divided into four groups. In group I rats (control, n = 10), only right nephrectomy was performed. Group 2 rats (untreated, n = 10) underwent right nephrectomy and the left ureter was completely obstructed. In group 3 rats (celecoxib), the same operation was performed as described for group 2 and than celecoxib was administered by gavage for a period of 24 h. Group 4 rats (piroxicam) underwent the same operation as described for group 2, then piroxicam was administered intramuscularly at least I h before the release of the for 24 h complete ureteric obstruction. All animals were then prepared for functional and histopathological studies. The administration of celecoxib produced a significant decrease in blood urea nitrogen levels when compared to the animals receiving piroxicam and the animals with no treatment. Moreover, celecoxib caused a significant decreased in creatinine levels when compared to the untreated group. Urine volume and the urinary sodium values were increased in the celecoxib group when compared with the other groups. The administration of celecoxib and piroxicam caused a significant decrease in the number of interstitial macrophages when compared to the untreated group. The Bowman space was significantly increased in the untreated group when compared with the celecoxib and the piroxicam groups. These studies indicate that celecoxib may be an important factor affecting renal morphological and functional changes after the release of a 24 h complete ureteric obstruction.en_US
dc.identifier.doi10.1007/s00240-002-0266-1
dc.identifier.endpage226en_US
dc.identifier.issn0300-5623
dc.identifier.issue4en_US
dc.identifier.pmid12202939
dc.identifier.scopus2-s2.0-0036929815
dc.identifier.scopusqualityN/A
dc.identifier.startpage223en_US
dc.identifier.urihttps://doi.org/10.1007/s00240-002-0266-1
dc.identifier.urihttps://hdl.handle.net/11468/14275
dc.identifier.volume30en_US
dc.identifier.wosWOS:000178318600004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer-Verlagen_US
dc.relation.ispartofUrological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclooxygenease-2en_US
dc.subjectCelecoxiben_US
dc.subjectPiroxicamen_US
dc.subjectUreteric Obstructionen_US
dc.subjectRaten_US
dc.titleRenal effects on a solitary kidney of specific inhibition of cyclooxygenease-2 after 24 h of complete ureteric obstruction in ratsen_US
dc.titleRenal effects on a solitary kidney of specific inhibition of cyclooxygenease-2 after 24 h of complete ureteric obstruction in rats
dc.typeArticleen_US

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