Effects of Nicotine on the Submandibular Gland in Rats

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dc.contributor.authorArslan, Eda
dc.contributor.authorSamanci, Baver
dc.contributor.authorSamanci, Seyla Bolukbasi
dc.contributor.authorCaypinar, Basak
dc.contributor.authorSengezer, Tijen
dc.contributor.authorDeveci, Engin
dc.contributor.authorSeker, Ugur
dc.date.accessioned2024-04-24T17:33:43Z
dc.date.available2024-04-24T17:33:43Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To evaluate the histopathologic and immunohistochemical effects of systemic use of nicotine on the submandibular glands. STUDY DESIGN: We investigated the effects of nicotine on apoptosis and angiogenesis. Twenty adult Sprague-Dawley rats were divided into 2 groups: nicotine (n=10) and controls (n=10). The rats of the nicotine group were administered 2 mg/kg nicotine sulphate for 28 days. All animals were sacrified at the end of the study, and submandibular samples were removed and prepared for histologic examination. Proliferating cell nuclear antigen (PCNA), vascular endothelial growth factor (VEGF), and Bcl-2 antibodies were used for immunohistochemical examination. RESULTS: In the group treated with nicotine, we observed degeneration in serous cells and striated duct cells, dilation and hemorrhage of blood vessels in the stromal area, and an increase of fibrous tissue and edema. An increase was observed in the number of PCNA-positive cells as compared to in the controls. VEGF expression was found to be positive in vascular endothelial cells and inflammatory cells around the excretory ducts in the stromal area. The duct cells are immunoreactive to Bcl-2 antibody. Apoptosis was observed in some cells of the serous glands and ducts. CONCLUSION: Nicotine administration in this study induced apoptosis with salivary gland cell proliferation and is thought to have affected angiogenesis.en_US
dc.identifier.endpage321en_US
dc.identifier.issn0884-6812
dc.identifier.issue5en_US
dc.identifier.pmid26856117
dc.identifier.scopus2-s2.0-84947938297
dc.identifier.scopusqualityQ4
dc.identifier.startpage317en_US
dc.identifier.urihttps://hdl.handle.net/11468/20812
dc.identifier.volume37en_US
dc.identifier.wosWOS:000367870000006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCigarette Smokingen_US
dc.subjectImmunohistochemistryen_US
dc.subjectNicotineen_US
dc.subjectRatsen_US
dc.subjectLaboratoryen_US
dc.subjectSmokingen_US
dc.subjectSubmandibular Glanden_US
dc.subjectSubmaxillary Glanden_US
dc.subjectTobacco Smokingen_US
dc.titleEffects of Nicotine on the Submandibular Gland in Ratsen_US
dc.titleEffects of Nicotine on the Submandibular Gland in Rats
dc.typeArticleen_US

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