Time-dependent changes in superoxide dismutase, catalase, xanthine dehydrogenase and oxidase activities in focal cerebral ischaemia

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dc.contributor.authorSermet, A
dc.contributor.authorTasdemir, N
dc.contributor.authorDeniz, B
dc.contributor.authorAtmaca, M
dc.date.accessioned2024-04-24T17:39:58Z
dc.date.available2024-04-24T17:39:58Z
dc.date.issued2000
dc.departmentDicle Üniversitesien_US
dc.description.abstractTime-dependent changes in the activities of antioxidant enzymes and an oxidant enzyme, xanthine oxidase (XO), were detected in primary and peri-ischaemic brain regions during permanent occlusion of the middle cerebral artery (MCAO) in rats. There were no changes in superoxide dismutase (SOD) and catalase (CAT) activities after 3 h of MCAO, whereas antioxidant enzyme activities decreased significantly in ischaemic brain areas following 24 h of ischaemia. After 48 h, the enzyme activities returned to the baseline but then a further increase was observed in ischaemic brain areas by 72 h post-ischaemia. Normally, XO exists as a dehydrogenase (XD), but it is converted to XO which contributes to injury in some ischaemic tissues. The XO activity increased slightly at 3 h after ischaemia, but after 24 h of ischaemia it returned to the baseline and then remained relatively unchanged in ischaemic areas. Pretreatment with allopurinol before ischaemia prevented changes in SOD and CAT activities and attenuated brain oedema during 24 h of ischaemia. Neither XO nor XD activity changed in allopurinol-treated rats at the times of ischaemia. These results indicated that ischaemic brain tissue remained vulnerable to free radical damage for as long as 48 h after ischaemia, and XO was probably not an important source of free radicals in cerebral ischaemia.en_US
dc.identifier.endpage172en_US
dc.identifier.issn0011-4529
dc.identifier.issue401en_US
dc.identifier.pmid10969880
dc.identifier.scopus2-s2.0-0033648480
dc.identifier.scopusqualityN/A
dc.identifier.startpage157en_US
dc.identifier.urihttps://hdl.handle.net/11468/21488
dc.identifier.volume102en_US
dc.identifier.wosWOS:000088312400003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherFaculty Pressen_US
dc.relation.ispartofCytobios
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrain Oedemaen_US
dc.subjectAntioxidant Enzymesen_US
dc.subjectFree Radicalsen_US
dc.subjectLipid Peroxidationen_US
dc.subjectCerebral Ischaemiaen_US
dc.subjectAllopurinolen_US
dc.titleTime-dependent changes in superoxide dismutase, catalase, xanthine dehydrogenase and oxidase activities in focal cerebral ischaemiaen_US
dc.titleTime-dependent changes in superoxide dismutase, catalase, xanthine dehydrogenase and oxidase activities in focal cerebral ischaemia
dc.typeArticleen_US

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