Association between A/C1166 gene polymorphism of the angiotensin II type 1 receptor and biventricular functions in patients with acute myocardial infarction

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dc.contributor.authorUlgen, Mehmet S.
dc.contributor.authorOzturk, Onder
dc.contributor.authorYazici, Mehmet
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorAlan, Sait
dc.contributor.authorKoc, Fatih
dc.contributor.authorTekes, Selahattin
dc.date.accessioned2024-04-24T17:15:03Z
dc.date.available2024-04-24T17:15:03Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground Although there have been several association studies of angiotensin II type 1 receptor (AT1R, A/C1166) gene polymorphism in clinical endpoints such as myocardial infarction (MI), hypertension, aortic stiffness, and left ventricular mass, the relationship between AT1R polymorphism and biventricular function in acute anterior MI has not been studied before. Methods and Results The study group comprised 132 consecutive patients who were admitted to the coronary care unit with their first acute anterior MI. Systolic and diastolic diameters, volumes, inflow properties, ejection fraction and myocardial performance index of both ventricles were measured. AT1R polymorphism was determined using polymerase chain reaction amplification. Based on A/C1166 polymorphism of ATIR, the patients were classified into 3 groups: group 1, A/A (n=91) genotype, group 2 A/C (n=28), and group 3 C/C (n=13) genotype. When the left ventricular and right ventricular echocardiographic functions were compared, all parameters of the 3 groups were found to be similar. No difference was detected in either the genotype distribution or allele frequencies between the patients and the controls for AT1R. Conclusions The results suggest that A/C1166 polymorphism of AT1R did not influence the risk of either acute MI or biventricular function after anterior MI.en_US
dc.identifier.doi10.1253/circj.70.1275
dc.identifier.endpage1279en_US
dc.identifier.issn1346-9843
dc.identifier.issue10en_US
dc.identifier.pmid16998258
dc.identifier.scopus2-s2.0-33749008540
dc.identifier.scopusqualityQ1
dc.identifier.startpage1275en_US
dc.identifier.urihttps://doi.org/10.1253/circj.70.1275
dc.identifier.urihttps://hdl.handle.net/11468/18315
dc.identifier.volume70en_US
dc.identifier.wosWOS:000240908400007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherJapanese Circulation Societyen_US
dc.relation.ispartofCirculation Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGene Polymorphismen_US
dc.subjectMyocardial Infarctionen_US
dc.subjectYentricular Functionen_US
dc.titleAssociation between A/C1166 gene polymorphism of the angiotensin II type 1 receptor and biventricular functions in patients with acute myocardial infarctionen_US
dc.titleAssociation between A/C1166 gene polymorphism of the angiotensin II type 1 receptor and biventricular functions in patients with acute myocardial infarction
dc.typeArticleen_US

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