Effects of mesenchymal stem cells in critical size bone defect

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dc.contributor.authorAgacayak, S.
dc.contributor.authorGulsun, B.
dc.contributor.authorUcan, M. C.
dc.contributor.authorKaraoz, E.
dc.contributor.authorNergiz, Y.
dc.date.accessioned2024-04-24T17:33:42Z
dc.date.available2024-04-24T17:33:42Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground and Objectives: The aim of this study was to compare culture-expanded, bone marrow-derived mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) loaded to biphasic calcium phosphate (BCP) bone ceramic in the repair of rat calvarial bone. Materials and Methods: Critical-size (7 mm dia.) calvarial defects were prepared in the frontal-parietal bones of 90 adult female Sprague-Dawley rats. Rats were randomly divided into 5 groups, according to defect filling, as follows: Group I (n=21), BCP; Group II (n=21), BCP+PRP; Group III (n=21), BCP+MSC; Group IV (n=21), BCP+PRP+MSC; Group V (n=6) (control), no treatment. Animals were sacrificed at 2, 8 and 12 weeks postsurgery and bone regeneration was evaluated both histologically and immunohistochemically. Results: Statistically significant differences were observed in bone osteoblastic activity in calvarial defects among the groups (p < 0.05). PRP and MSC used in combination with BCP as a defect filling resulted in greater osteoblastic bone formation activity when compared to the use of BCP alone. Conclusions: The combination of mesenchymal stem cells, platelet rich plasma and synthetic bone substitute was found to be more effective in inducing new bone formation (osteogenesis) than the use of platelet rich plasma combined with synthetic bone substitute and the use of synthetic bone substitute alone.en_US
dc.identifier.endpage686en_US
dc.identifier.issn1128-3602
dc.identifier.issue5en_US
dc.identifier.pmid22774411
dc.identifier.scopus2-s2.0-84864112865
dc.identifier.scopusqualityQ2
dc.identifier.startpage679en_US
dc.identifier.urihttps://hdl.handle.net/11468/20809
dc.identifier.volume16en_US
dc.identifier.wosWOS:000305663400017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStem Cellen_US
dc.subjectOral And Maxillofacial Surgeryen_US
dc.subjectBone Healingen_US
dc.titleEffects of mesenchymal stem cells in critical size bone defecten_US
dc.titleEffects of mesenchymal stem cells in critical size bone defect
dc.typeArticleen_US

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