Complete genome sequences and phylogenetic analysis of hepatitis delta viruses isolated from nine Turkish patients

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dc.contributor.authorCelik, Inci
dc.contributor.authorKaratayli, Ersin
dc.contributor.authorCevik, Emrah
dc.contributor.authorKabakci, S. Gokce
dc.contributor.authorKaratayli, Senem Ceren
dc.contributor.authorDinc, Bedia
dc.contributor.authorCmar, Kubilay
dc.date.accessioned2024-04-24T16:01:57Z
dc.date.available2024-04-24T16:01:57Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractHepatitis delta virus (HDV) is a subviral agent of hepatitis B virus (HBV), and its life cycle is dependent on HBV. It is commonly accepted that HDV has eight distinct genotypes. In this study, the complete nucleotide sequences of HDV genomes isolated from nine Turkish patients were obtained by RT-PCR using two pairs of primers that cover the entire HDV genome. PCR products were sequenced directly. The results showed that these 9 isolates were approximately 1680 base pairs in length and clustered in the genotype HDV-1 branch when phylogenetic analysis was done with the sequences together with the complete sequences of HDV genomes representing each genotype retrieved from GenBank. Analysis of a portion of the large hepatitis D antigen (L-HDAg) gene showed that sequence similarity among these Turkish isolates is between 87.4 and 97.1%, and the Turkish isolates have the most sequence similarity to HDV-1 (90.5%), while they have the least sequence similarity to HDV-3 (64.1%). Full-genome analysis indicates that the sequence similarity is between 80.7 and 95.4%, and the highest sequence similarity is 84.8% (between the Turkish isolates and HDV-1). The lowest sequence similarity is 56.4% (between the Turkish isolates and HDV-3). In conclusion, phylogenetic analysis shows that the Turkish HDV isolates belong to HDV-1.en_US
dc.identifier.doi10.1007/s00705-011-1120-y
dc.identifier.endpage2220en_US
dc.identifier.issn0304-8608
dc.identifier.issn1432-8798
dc.identifier.issue12en_US
dc.identifier.pmid21984217
dc.identifier.scopus2-s2.0-82455162589
dc.identifier.scopusqualityQ3
dc.identifier.startpage2215en_US
dc.identifier.urihttps://doi.org/10.1007/s00705-011-1120-y
dc.identifier.urihttps://hdl.handle.net/11468/14527
dc.identifier.volume156en_US
dc.identifier.wosWOS:000297706400011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Wienen_US
dc.relation.ispartofArchives of Virology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleComplete genome sequences and phylogenetic analysis of hepatitis delta viruses isolated from nine Turkish patientsen_US
dc.titleComplete genome sequences and phylogenetic analysis of hepatitis delta viruses isolated from nine Turkish patients
dc.typeArticleen_US

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