Prognostic factors in elderly patients with advanced non-small cell lung cancer treated with first-line cisplatin-based chemotherapy: A retrospective analysis of single institution

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dc.contributor.authorInal, A.
dc.contributor.authorKaplan, M. A.
dc.contributor.authorKucukoner, M.
dc.contributor.authorKarakus, A.
dc.contributor.authorIsikdogan, A.
dc.date.accessioned2024-04-24T17:37:50Z
dc.date.available2024-04-24T17:37:50Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: Non-small cell lung cancer (NSCLC) makes up 80-85% of all lung cancers cases. Lung cancer in older individuals is frequently undertreated. Patients eligible for cisplatin-based chemotherapy should be selected carefully. The aim of this retrospective single-center study was to evaluate prognostic factors for overall survival (OS) in elderly (>= 65 years) patients with advanced NSCLC who received first-line cisplatin-based chemotherapy. Methods: We retrospectively reviewed 110 elderly patients with locally advanced or metastatic NSCLC who had been administered cisplatin-based first-line chemotherapy between December 2004 and November 2011. Seventeen potential prognostic variables were chosen for analysis. Univariate and multivariate analyses were conducted to identify prognostic factors associated with OS. Results: Among the 17 variables of univariate analysis, 4 were identified to have prognostic significance for OS: comorbidities (p<0.001), Eastern Cooperative Oncology Group (ECOG) performance status (PS) (p=0.02), first-line chemotherapy cycles (p<0.001) and serum albumin level (p=0.04). Multivariate analysis showed that only ECOG PS (p=0.01) was independent prognostic factor for OS. Conclusion: PS was important prognostic factor in elderly patients with advanced NSCLC. The findings of this study may facilitate pretreatment prediction of OS and therefore can be used for selecting the most appropriate treatment for elderly patients.en_US
dc.identifier.endpage536en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue3en_US
dc.identifier.pmid23033295
dc.identifier.scopus2-s2.0-84867535247
dc.identifier.scopusqualityQ3
dc.identifier.startpage533en_US
dc.identifier.urihttps://hdl.handle.net/11468/21207
dc.identifier.volume17en_US
dc.identifier.wosWOS:000309793000021
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherImprimatur Publicationsen_US
dc.relation.ispartofJournal of Buon
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdvanced Lung Canceren_US
dc.subjectCisplatin-Based Chemotherapyen_US
dc.subjectElderly Patientsen_US
dc.subjectPrognostic Factorsen_US
dc.subjectSurvivalen_US
dc.titlePrognostic factors in elderly patients with advanced non-small cell lung cancer treated with first-line cisplatin-based chemotherapy: A retrospective analysis of single institutionen_US
dc.titlePrognostic factors in elderly patients with advanced non-small cell lung cancer treated with first-line cisplatin-based chemotherapy: A retrospective analysis of single institution
dc.typeArticleen_US

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