Effect of oxidative stress on antioxidant enzyme activities, homocysteine and lipoproteins in chronic kidney disease

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dc.contributor.authorAtamer, Aytac
dc.contributor.authorKocyigit, Yuksel
dc.contributor.authorEcder, Sabahat Alisir
dc.contributor.authorSelek, Sahabettin
dc.contributor.authorIlhan, Nevin
dc.contributor.authorEcder, Tevfik
dc.contributor.authorAtamer, Yildiz
dc.date.accessioned2024-04-24T17:33:36Z
dc.date.available2024-04-24T17:33:36Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Our aim was to determine the association of paraoxonase (PON1), superoxide dismutase (SOD) and catalase (CAT) activities and malondialdehyde (MDA) concentration, with lipoprotein and homocysteine (Hcy) concentrations in chronic kidney disease (CKD). Methods: We examined 60 patients with CKD (35 men and 25 women), aged 52.7 +/- 3.1 years, and 60 age-, sex- and body mass index (BMI)-matched control subjects. Serum PON1 activity, levels of lipoproteins, Hcy and MDA were evaluated; SOD and CAT activities in erythrocytes were also investigated. Results: Levels of MDA, lipoprotein (a) (Lp(a)) and Hcy were significantly higher, while PON1 activity was lower in CKD than in controls (p<0.001). There were no significant differences between the patients and controls in the SOD and CAT activities (p>0.05). Levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (ApoA-I) were lower in CKD than in controls (p<0.001), whereas total cholesterol (T-Chol) and triglyceride (TG) levels showed no significant difference between the groups. Levels of apolipoprotein B (ApoB) and low-density lipoprotein cholesterol (LDL-C) were higher in CKD than in controls (p<0.001). In CKD, PON1 activities were correlated with levels of Hcy, MDA, HDL-C, Lp(a) and ApoA-I. A significant positive correlation was found between levels of Hcy and Lp(a). Conclusions: The results of this work suggest that patients with CKD exhibit an oxidant-antioxidant imbalance which is closely related to high levels of atherosclerotic risk factors.en_US
dc.identifier.endpage930en_US
dc.identifier.issn1121-8428
dc.identifier.issn1724-6059
dc.identifier.issue6en_US
dc.identifier.pmid19034878
dc.identifier.scopus2-s2.0-62749156511
dc.identifier.scopusqualityQ1
dc.identifier.startpage924en_US
dc.identifier.urihttps://hdl.handle.net/11468/20765
dc.identifier.volume21en_US
dc.identifier.wosWOS:000269099600016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofJournal of Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCatalaseen_US
dc.subjectHomocysteineen_US
dc.subjectLipoproteinsen_US
dc.subjectOxidative Stressen_US
dc.subjectParaoxonaseen_US
dc.subjectSuperoxide Dismutaseen_US
dc.titleEffect of oxidative stress on antioxidant enzyme activities, homocysteine and lipoproteins in chronic kidney diseaseen_US
dc.titleEffect of oxidative stress on antioxidant enzyme activities, homocysteine and lipoproteins in chronic kidney disease
dc.typeArticleen_US

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