Immunohistochemical localization of epidermal growth factor system in the lung of the Japanese quail (Coturnix coturnix japonica) during the post-hatching period

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dc.contributor.authorAlan, Emel
dc.contributor.authorLiman, Narin
dc.contributor.authorSağsöz, Hakan
dc.date.accessioned2024-04-24T15:59:26Z
dc.date.available2024-04-24T15:59:26Z
dc.date.issued2015
dc.departmentDicle Üniversitesi, Veteriner Fakültesi, Temel Bilimler Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractThe purpose of this study is to determine the possible changes in the localization of the four Epidermal Growth Factor Receptors and three ligands in quail lungs from the first day of hatching until the 125th after hatching using immunohistochemical methods. Immunohistochemical results demonstrated that four EGFRs and their ligands are chiefly located in the cytoplasm of cells. Additionally, ErbB4, AREG, and NRG1 are localized to the nucleus and nucleolus, but EGF is present in the nucleolus. ErbB2 was also found in the cell membrane. In the epithelium of secondary bronchi, the goblet cells only exhibited ErbB1 and ErbB2, whereas the basal and ciliated cells exhibited EGFRs and ligands immunoreactivity. The atrial granular cells displayed moderate levels of ErbB1-ErbB3 and EGF and strong levels of ErbB4, AREG, and NRG1 immunoreactivity. While the squamous atrial cells and squamous respiratory cells of air capillaries and endothelial cells of blood capillaries exhibited moderate to strong ErbB2, ErbB4, AREG, and NRG1 immunoreactivity, they had negative or weak ErbB1, ErbB3, and EGF immunoreactivity. The expression levels of ErbB2-ErbB4, EGF, AREG, and NRG1 were also detected in fibroblasts. Although ErbB2 was highly expressed in the bronchial and vascular smooth muscle cells, weak expression of ErbB1, ErbB3, AREG and EGF and moderate expression of ErbB4 and NRG1 were observed. Macrophages were only negative for ErbB1. In conclusion, these data indicate that the EGFR-system is functionally active at hatching, which supports the hypothesis that the members of EGFR-system play several cell-specific roles in quail lung growth after hatching.en_US
dc.identifier.citationAlan, E., Liman, N. ve Sağsöz, H. (2015). Immunohistochemical localization of epidermal growth factor system in the lung of the Japanese quail (Coturnix coturnix japonica) during the post-hatching period. Microscopy Research and Technique, 78(9), 807-822.
dc.identifier.doi10.1002/jemt.22544
dc.identifier.endpage822en_US
dc.identifier.issn1059-910X
dc.identifier.issn1097-0029
dc.identifier.issue9en_US
dc.identifier.pmid26179370
dc.identifier.scopus2-s2.0-84939651171
dc.identifier.scopusqualityQ1
dc.identifier.startpage807en_US
dc.identifier.urihttps://doi.org/10.1002/jemt.22544
dc.identifier.urihttps://hdl.handle.net/11468/14070
dc.identifier.urihttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jemt.22544
dc.identifier.volume78en_US
dc.identifier.wosWOS:000360378500009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSağsöz, Hakan
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofMicroscopy Research and Technique
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpidermal growth factor receptorsen_US
dc.subjectAmphiregulinen_US
dc.subjectPosthatchingen_US
dc.subjectQuailen_US
dc.subjectLungen_US
dc.titleImmunohistochemical localization of epidermal growth factor system in the lung of the Japanese quail (Coturnix coturnix japonica) during the post-hatching perioden_US
dc.titleImmunohistochemical localization of epidermal growth factor system in the lung of the Japanese quail (Coturnix coturnix japonica) during the post-hatching period
dc.typeReview Articleen_US

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