A Study on the Effects of the Use of Propofol in Experimental Model Inferior Epigastric Island Flap on Ischemia-Reperfusion Injury

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dc.contributor.authorEroglu, Tuncay
dc.contributor.authorBozkurt, Mehmet
dc.contributor.authorKapi, Emin
dc.contributor.authorSelcuk, Caferi Tayyar
dc.contributor.authorKuvat, Samet Vasfi
dc.contributor.authorTufek, Adnan
dc.contributor.authorIsik, Fatma Birgul
dc.date.accessioned2024-04-24T17:08:31Z
dc.date.available2024-04-24T17:08:31Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractProblems concerning vascular blood flow are the most frequently encountered ones after flap applications. The flap tissue starts to develop ischemia in patients with a vascular blood flow insufficiency. And reperfusion starts in those patients in whom the ischemia is temporary, triggering an ischemia-reperfusion injury depending on the duration of the ischemia. The aim of this study was to evaluate the effect of propofol, which is an anesthetic agent known to have an antioxidant effect and a free radical scavenging feature on the ischemia-reperfusion injury created on an experimental epigastric island flap. Thirty Sprague-Dawley rats were used in the study. The rats were divided into 3 groups of 10 rats each. Inferior epigastric artery-based abdominal flaps were prepared in all the groups. In group 1 (sham), the flap was elevated but no ischemia was applied. In groups 2 (control) and 3 (propofol), the flap was exposed to ischemia for 2hours after it was elevated. All the rats were sacrificed and biochemical and histopathological assessments were made on the tissue samples taken on the 14th day. As a result of a comparison between the groups, the flap viability rates and the superoxide dismutase, total antioxidant capacity, and catalase values were found to be significantly higher (P<0.001) in the propofol group while the malondialdehyde and total oxidative stress values were lower (P<0.001). Based on the data obtained from the present study, the use of propofol was observed to have a protective effect against ischemia-reperfusion injuries in flap surgeries.en_US
dc.identifier.doi10.1097/SCS.0000000000004049
dc.identifier.endpage2198en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue8en_US
dc.identifier.pmid28968324
dc.identifier.scopus2-s2.0-85047342996
dc.identifier.scopusqualityQ3
dc.identifier.startpage2193en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000004049
dc.identifier.urihttps://hdl.handle.net/11468/17370
dc.identifier.volume28en_US
dc.identifier.wosWOS:000415085100111
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Craniofacial Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnesthesiaen_US
dc.subjectFlapen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectPropofolen_US
dc.titleA Study on the Effects of the Use of Propofol in Experimental Model Inferior Epigastric Island Flap on Ischemia-Reperfusion Injuryen_US
dc.titleA Study on the Effects of the Use of Propofol in Experimental Model Inferior Epigastric Island Flap on Ischemia-Reperfusion Injury
dc.typeArticleen_US

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