Increased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism

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dc.contributor.authorZoroglu, SS
dc.contributor.authorArmutcu, F
dc.contributor.authorOzen, S
dc.contributor.authorGurel, A
dc.contributor.authorSivasli, E
dc.contributor.authorYetkin, O
dc.contributor.authorMeram, I
dc.date.accessioned2024-04-24T16:01:53Z
dc.date.available2024-04-24T16:01:53Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractThere is great evidence in recent years that oxygen free radicals play an important role in the pathophysiology of many neuropsychiatric disorders. The present study was performed to assess the changes in red blood cells thiobarbituric acid-reactive substances (TBARS) levels, and superoxide dismutase (SOD), catalase (CAT), adenosine deaminase (ADA) and xanthine oxidase (XO) activities in patients with autism (n = 27) compared to age- and sex-matched normal controls (n = 26). In the autistic group, increased TBARS levels (p < 0.001) and XO (p < 0.001) and SOD (p < 0.001) activity, decreased CAT (p < 0.001) activity and unchanged ADA activity were detected. It is proposed that antioxidant status may be changed in autism and this new situation may induce lipid peroxidation. These findings indicated a possible role of increased oxidative stress and altered enzymatic antioxidants, both of which may be relevant to the pathophysiology of autism.en_US
dc.identifier.doi10.1007/s00406-004-0456-7
dc.identifier.endpage147en_US
dc.identifier.issn0940-1334
dc.identifier.issn1433-8491
dc.identifier.issue3en_US
dc.identifier.pmid15205966
dc.identifier.scopus2-s2.0-4243077662
dc.identifier.scopusqualityQ1
dc.identifier.startpage143en_US
dc.identifier.urihttps://doi.org/10.1007/s00406-004-0456-7
dc.identifier.urihttps://hdl.handle.net/11468/14453
dc.identifier.volume254en_US
dc.identifier.wosWOS:000222319300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofEuropean Archives of Psychiatry and Clinical Neuroscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutismen_US
dc.subjectThiobarbituric Acid-Reactive Substances (Tbars)en_US
dc.subjectSuperoxide Dismutase (Sod)en_US
dc.subjectCatalase (Cat)en_US
dc.subjectXanthine Oxidase (Xo)en_US
dc.subjectAdenosine Deaminase (Ada)en_US
dc.subjectFree Radicalsen_US
dc.titleIncreased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autismen_US
dc.titleIncreased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism
dc.typeArticleen_US

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