No evidence for an association between the T102C and 1438 G/A polymorphisms of the serotonin 2A receptor gene in attention deficit/hyperactivity disorder in a Turkish population

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dc.contributor.authorZoroglu, SS
dc.contributor.authorErdal, ME
dc.contributor.authorErdal, N
dc.contributor.authorOzen, S
dc.contributor.authorAlasehirli, B
dc.contributor.authorSivasli, E
dc.date.accessioned2024-04-24T17:14:26Z
dc.date.available2024-04-24T17:14:26Z
dc.date.issued2003
dc.departmentDicle Üniversitesien_US
dc.description.abstractDisturbances in the serotonergic neurotransmission system have been implicated in the etiology of attenion deficit/hyperactivity disorder (ADHD). As the importance of genetic factors is well established, genes encoding for proteins of the serotonergic pathway are important candidates to unravel the underlying genetic contribution. We previously demonstrated that the polymorphisms of the serotonin transporter gene promoter and regions of variable number of tandem repeats were involved in the pathogenesis of ADHD. The purpose of this study was to examine the relationship between ADHD and two polymorphisms (T102C and 1438 G/A) in the 5-HT2A gene in a sample of Turkish children. Using the PCR technique, these polymorphisms were assessed in 70 patients with ADHD and in 100 healthy controls. There was no significant difference between the frequencies of the T, C, G and A alleles of both groups. No association was found between the studied polymorphisms of the 5-HT2A gene and ADHD in this sample consisting of Turkish children. Overall, our results suggest that the investigated 5-HT2A polymorphisms are not major susceptibility factors in the etiology of ADHD. Copyright (C) 2003 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000068870
dc.identifier.endpage20en_US
dc.identifier.issn0302-282X
dc.identifier.issn1423-0224
dc.identifier.issue1en_US
dc.identifier.pmid12606840en_US
dc.identifier.scopus2-s2.0-0037262625en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage17en_US
dc.identifier.urihttps://doi.org/10.1159/000068870
dc.identifier.urihttps://hdl.handle.net/11468/17940
dc.identifier.volume47en_US
dc.identifier.wosWOS:000181613600003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofNeuropsychobiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAttention Deficit/Hyperactivity Disorder Polymorphismen_US
dc.subjectT102cen_US
dc.subject1438 G/Aen_US
dc.subject5-Ht2aen_US
dc.titleNo evidence for an association between the T102C and 1438 G/A polymorphisms of the serotonin 2A receptor gene in attention deficit/hyperactivity disorder in a Turkish populationen_US
dc.typeArticleen_US

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