Intravenous pharmacokinetics of moxifloxacin following simultaneous administration with flunixin meglumine or diclofenac in sheep

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dc.contributor.authorAltan, Feray
dc.contributor.authorCorum, Orhan
dc.contributor.authorYildiz, Ramazan
dc.contributor.authorFaki, Hatice Eser
dc.contributor.authorIder, Merve
dc.contributor.authorOk, Mahmut
dc.contributor.authorUney, Kamil
dc.date.accessioned2024-04-24T17:11:47Z
dc.date.available2024-04-24T17:11:47Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn this study, the pharmacokinetics of moxifloxacin (5 mg/kg) was determined following a single intravenous administration of moxifloxacin alone and co-administration with diclofenac (2.5 mg/kg) or flunixin meglumine (2.2 mg/kg) in sheep. Six healthy Akkaraman sheep (2 +/- 0.3 years and 53.5 +/- 5 kg of body weight) were used. A longitudinal design with a 15-day washout period was used in three periods. In the first period, moxifloxacin was administered by an intravenous (IV) injection. In the second and third periods, moxifloxacin was co-administered with IV administration of diclofenac and flunixin meglumine, respectively. The plasma concentration of moxifloxacin was assayed by high-performance liquid chromatography. The pharmacokinetic parameters were calculated using a two-compartment open pharmacokinetic model. Following IV administration of moxifloxacin alone, the mean elimination half-life (t(1/2 beta)), total body clearance (Cl-T), volume of distribution at steady state (V-dss) and area under the curve (AUC) of moxifloxacin were 2.27 hr, 0.56 L h(-1) kg(-1), 1.66 L/kg and 8.91 hr*mu g/ml, respectively. While diclofenac and flunixin meglumine significantly increased the t(1/2 beta) and AUC of moxifloxacin, they significantly reduced the Cl-T and V-dss. These results suggest that anti-inflammatory drugs could increase the therapeutic efficacy of moxifloxacin by altering its pharmacokinetics.en_US
dc.description.sponsorshipCoordination of Scientific Research Projects, University of Selcuk, Turkey [17401058]en_US
dc.description.sponsorshipThe Coordination of Scientific Research Projects, University of Selcuk, Turkey, Grant/Award Number: 17401058en_US
dc.identifier.doi10.1111/jvp.12841
dc.identifier.endpage114en_US
dc.identifier.issn0140-7783
dc.identifier.issn1365-2885
dc.identifier.issue2en_US
dc.identifier.pmid32043623
dc.identifier.scopus2-s2.0-85079713561
dc.identifier.scopusqualityQ1
dc.identifier.startpage108en_US
dc.identifier.urihttps://doi.org/10.1111/jvp.12841
dc.identifier.urihttps://hdl.handle.net/11468/17720
dc.identifier.volume43en_US
dc.identifier.wosWOS:000512441400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiclofenacen_US
dc.subjectFlunixin Meglumineen_US
dc.subjectMoxifloxacinen_US
dc.subjectPharmacokineticsen_US
dc.subjectSheepen_US
dc.titleIntravenous pharmacokinetics of moxifloxacin following simultaneous administration with flunixin meglumine or diclofenac in sheepen_US
dc.titleIntravenous pharmacokinetics of moxifloxacin following simultaneous administration with flunixin meglumine or diclofenac in sheep
dc.typeArticleen_US

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