Astaxanthin protects against hearing impairment in diabetic rats

Basit Öğe Kaydı
dc.authorid0000-0003-3879-8794en_US
dc.authorid0000-0001-6276-8355en_US
dc.contributor.authorToprak, Serdar Ferit
dc.contributor.authorDedeoğlu, Serkan
dc.date.accessioned2024-03-04T11:03:42Z
dc.date.available2024-03-04T11:03:42Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun ve Boğaz Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractObjective: Diabetes Mellitus (DM) causes an increase in oxidative stress that leads to deterioration in auditory functions. Astaxanthine (AST) is known to have strong antioxidant effects. In this study, the aim is to investigate the effect of AST against hearing loss that is due to DM. Methods: This study is an experimental animal study. The study was designed in four groups with 8 animals (n = 8) in each group. The groups were as follows; Control Group (CNT), Diabetic Group (DM), AST applied diabetic group (DM+AST), and AST applied non-diabetic group (AST). Streptozotocin was applied in rats to induce DM. AST was administered by oral gavage. Auditory Brainstem Responses (ABR) and Distortion Product Otoacoustic Emissions (DPOAE) tests were performed on several days of the study. At the end of the study, pro-inflammatory cytokine levels were analyzed in cochlear tissue samples, and Glutathione Peroxidase (GPx), Superoxide Dismutase (SOD), Catalase (CAT) and Malondialdehyde (MDA) levels were measured. Results: When the findings obtained in the ABR and DPOAE tests in the DM group, it was observed that there was a significant deterioration in the hearing sense. This deterioration was not observed in the DM+AST group. In the DM group, GPx, SOD and CAT levels decreased and MDA levels increased in blood and cochlear tissue. Compared to the DM group, it was noted that antioxidant enzyme levels increased and MDA levels decreased in the DM+AST group. Cochlear tissue pro-inflammatory cytokine levels, which increased with DM, were significantly decreased in the DM+AST group. Conclusion: Even though the effects of AST were investigated in a diabetic experimental animal model, if this molecule is proven to be effective in diabetic humans, it can be considered an adjunct therapeutic option with its antioxidant effects. Level of evidence: The level of evidence of this article is 5. This article is an experimental animal and laboratory study.en_US
dc.identifier.citationToprak, S. F. ve Dedeoğlu, S. (2022). Astaxanthin protects against hearing impairment in diabetic rats. Brazilian Journal of Otorhinolaryngology, 88(Supplement 3), S73-S80.en_US
dc.identifier.doi10.1016/j.bjorl.2022.02.004
dc.identifier.endpageS80en_US
dc.identifier.issn1808-8694
dc.identifier.issueSupplement 3en_US
dc.identifier.pmid35331657
dc.identifier.scopus2-s2.0-85126928847
dc.identifier.scopusqualityQ2
dc.identifier.startpageS73en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1808869422000234?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/13483
dc.identifier.volume88en_US
dc.identifier.wosWOS:001042080400010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorToprak, Serdar Ferit
dc.language.isoenen_US
dc.publisherElsevier Editora Ltdaen_US
dc.relation.ispartofBrazilian Journal of Otorhinolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAstaxanthinen_US
dc.subjectDiabetes mellitusen_US
dc.subjectHearing lossen_US
dc.subjectPro-inflammatory cytokinesen_US
dc.titleAstaxanthin protects against hearing impairment in diabetic ratsen_US
dc.titleAstaxanthin protects against hearing impairment in diabetic rats
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Astaxanthin protects against hearing impairment in diabetic rats.pdf
Boyut:
1.09 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Cerrahi Tıp Bilimleri Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu