Impact of neutrophil-to-lymphocyte ratio on stroke severity and clinical outcome in anterior circulation large vessel occlusion stroke

Basit Öğe Kaydı
dc.authorid0000-0002-3717-5272
dc.authorid0000-0002-3317-9567
dc.authorid0009-0005-6098-5096
dc.authorid0000-0003-2001-914X
dc.authorid0000-0002-4619-693X
dc.authorid0000-0002-5985-900X
dc.authorid0000-0002-0076-9405
dc.authorid0000-0001-9669-6804
dc.contributor.authorMemiş, Zülfikar
dc.contributor.authorGürkaş, Erdem
dc.contributor.authorÖzdemir, Atilla Özcan
dc.contributor.authorAcar, Bilgehan Atılgan
dc.contributor.authorÖğün, Muhammed Nur
dc.contributor.authorAytaç, Emrah
dc.contributor.authorAkpınar, Çetin Kürşad
dc.contributor.authorAkıl, Eşref
dc.date.accessioned2025-02-22T14:08:40Z
dc.date.available2025-02-22T14:08:40Z
dc.date.issued2024
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.description.abstractBackground: The prognostic value of the neutrophil-lymphocyte ratio (NLR) in ischemic stroke remains debated due to cohort variability and treatment heterogeneity across studies. This study evaluates the relationship between admission NLR, stroke severity and 90-day outcomes in patients with anterior circulation large vessel occlusion (LVO) undergoing early, successful revascularization. Methods: A retrospective multicenter study was conducted with 1082 patients treated with mechanical thrombectomy for acute ischemic stroke. The relationship between admission NLR, baseline National Institutes of Health Stroke Scale (NIHSS), 24 h NIHSS and 90-day modified Rankin Scale (mRS) outcomes was analyzed using logistic regression. Results: Admission NLR correlated weakly but significantly with both baseline (p = 0.018) and 24 h (p = 0.005) NIHSS scores, reflecting stroke severity. However, multivariate analysis showed that higher 24 h NIHSS scores (OR 0.831, p = 0.000) and prolonged puncture-to-recanalization times (OR 0.981, p = 0.000) were independent predictors of poor 90-day outcomes, whereas NLR was not (p = 0.557). Conclusions: Admission NLR is associated with stroke severity but does not independently predict clinical outcomes at 90 days in patients achieving early and successful revascularization. These findings underscore the critical role of inflammation in the acute phase of stroke but suggest that its prognostic value for long-term outcomes is limited in this context.en_US
dc.identifier.citationMemiş, Z., Gürkaş, E., Özdemir, A. Ö., Acar, B. A., Öğün, M. N., Aytaç, E. ve diğerleri. (2024). Impact of neutrophil-to-lymphocyte ratio on stroke severity and clinical outcome in anterior circulation large vessel occlusion stroke. Diagnostics, 14(24), 1-13.
dc.identifier.doi10.3390/diagnostics14242880
dc.identifier.issn2075-4418
dc.identifier.issue24en_US
dc.identifier.pmid39767241en_US
dc.identifier.scopus2-s2.0-85213300936en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/diagnostics14242880
dc.identifier.urihttps://hdl.handle.net/11468/29558
dc.identifier.volume14en_US
dc.identifier.wosWOS:001384948500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkıl, Eşref
dc.institutionauthorid0000-0001-9669-6804
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofDiagnosticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectStrokeen_US
dc.subjectNeutrophil-lymphocyte ratioen_US
dc.subjectInflammationen_US
dc.subjectPrognostic biomarkersen_US
dc.subjectMechanical thrombectomyen_US
dc.titleImpact of neutrophil-to-lymphocyte ratio on stroke severity and clinical outcome in anterior circulation large vessel occlusion strokeen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Impact of Neutrophil-to-Lymphocyte Ratio on Stroke Severity and Clinical Outcome in Anterior Circulation Large Vessel Occlusion Stroke.pdf
Boyut:
684.95 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Dahili Tıp Bilimleri Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu