Paraoxonase, anti-oxidant response and oxidative stress in children with chronic renal failure

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dc.contributor.authorEce, A
dc.contributor.authorAtamer, Y
dc.contributor.authorGürkan, F
dc.contributor.authorDavutoglu, M
dc.contributor.authorBilici, M
dc.contributor.authorTutanç, M
dc.contributor.authorGünes, A
dc.date.accessioned2024-04-24T16:01:54Z
dc.date.available2024-04-24T16:01:54Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractIncreased oxidative stress is believed to contribute to an increased risk of cardiovascular disease in uraemia. In children with chronic renal failure (CRF), an anti-oxidant enzyme, paraoxonase (PON), that inhibits oxidation of LDL-cholesterol, has not been previously investigated. In this study we aimed to investigate PON activity, total anti-oxidant response (TAR), total peroxide (TPX), oxidative stress index (OSI) and some pro-oxidant cytokines in 29 children with CRF [mean age 10.2 +/- 3.5 years; 19 pre-dialysis, ten on continuous ambulatory peritoneal dialysis (CAPD)] and in 25 control subjects. Children with CRF had lower PON and TAR and higher TPX and OSI values than did controls (P<0.05). Except for lower TAR and serum albumin levels of the CAPD subgroup (P<0.05), other parameters were similar in non-dialysis and CAPD patients (P>0.05). Patients had significant positive correlation between TAR and serum albumin (P<0.05). Serum urea had significant positive correlation with TPX and OSI (P<0.05). Increased oxidative stress and decreased anti-oxidants measured by serum PON activity and TAR were found in children with CRF. We can hypothesize, on the basis of statistical correlations, that low levels of serum albumin and high levels of uraemic metabolites might be responsible for increased oxidative stress in children with CRF. Further studies with larger sample sizes are needed to verify these results.en_US
dc.identifier.doi10.1007/s00467-005-2079-2
dc.identifier.endpage245en_US
dc.identifier.issn0931-041X
dc.identifier.issn1432-198X
dc.identifier.issue2en_US
dc.identifier.pmid16252096
dc.identifier.scopus2-s2.0-30944459948
dc.identifier.scopusqualityQ1
dc.identifier.startpage239en_US
dc.identifier.urihttps://doi.org/10.1007/s00467-005-2079-2
dc.identifier.urihttps://hdl.handle.net/11468/14483
dc.identifier.volume21en_US
dc.identifier.wosWOS:000234603500015
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlbuminen_US
dc.subjectChildrenen_US
dc.subjectChronic Renal Failureen_US
dc.subjectCytokinesen_US
dc.subjectOxidative Stressen_US
dc.subjectParaoxonaseen_US
dc.titleParaoxonase, anti-oxidant response and oxidative stress in children with chronic renal failureen_US
dc.titleParaoxonase, anti-oxidant response and oxidative stress in children with chronic renal failure
dc.typeArticleen_US

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