Is montelukast as effective as N-acetylcysteine in hepatic injury due to acetaminophen intoxication in rats?

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dc.contributor.authorIcer, Mustafa
dc.contributor.authorZengin, Yilmaz
dc.contributor.authorGunduz, Ercan
dc.contributor.authorDursun, Recep
dc.contributor.authorDurgun, Hasan Mansur
dc.contributor.authorTurkcu, Gul
dc.contributor.authorYuksel, Hatice
dc.date.accessioned2024-04-24T16:11:27Z
dc.date.available2024-04-24T16:11:27Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study aims to investigate the acute protective effect of montelukast sodium in hepatic injury secondary to acetaminophen (APAP) intoxication. This study used 60 rats. The rats were grouped into 6 groups. The control group was administered oral distilled water 10 ml/kg, the APAP group oral APAP 1 g/kg, the montelukast sodium (MM) group oral MK 30 mg/kg, the acetaminophen + N-acetylcysteine (APAP + NAC) group oral APAP 1 g/kg, followed by a single dose of intraperitoneal NAC 1.5 g/kg three hours later, the acetaminophen + montelukast sodium (APAP+MK) group oral APAP 1 g/kg, followed by oral MK 30 mg/kg 3 h later, the acetaminophen + Nacetylcysteine + montelukast sodium (APAP + NAC + MM) group oral APAP 1 g/kg, followed by a single intraperitoneal NAC 1.5 g/kg plus oral MK 30 mg/kg 3 h later. Blood and liver tissue samples were taken 24 h after drug administration. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total bilirubin were studied from the blood samples. Liver tissue samples were used for histopathological examination. Compared with the control group, serum AST and ALT activities were higher in the APAP and APAP + NAC groups. APAP + NAC, APAP + MK, and APAP + NAC + MM groups had reduced serum ALT and AST activities than the group administered APAP alone. APAP + MM and APAP + NAC + MK groups had a lower serum ALP activity than the control group. Histopathologically, there was a difference between the group administered APAP alone and the APAP + MK and APAP + NAC + MK groups. MK is as protective as NAC in liver tissue in APAP intoxication in rats. (C) 2015 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.etp.2015.09.008
dc.identifier.endpage59en_US
dc.identifier.issn0940-2993
dc.identifier.issn1618-1433
dc.identifier.issue1en_US
dc.identifier.pmid26462568
dc.identifier.scopus2-s2.0-84951116909
dc.identifier.scopusqualityN/A
dc.identifier.startpage55en_US
dc.identifier.urihttps://doi.org/10.1016/j.etp.2015.09.008
dc.identifier.urihttps://hdl.handle.net/11468/15397
dc.identifier.volume68en_US
dc.identifier.wosWOS:000367486700006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofExperimental and Toxicologic Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMontelukast Sodiumen_US
dc.subjectAcetaminophenen_US
dc.subjectHepatotoxicityen_US
dc.subjectNacen_US
dc.subjectHistopathologyen_US
dc.titleIs montelukast as effective as N-acetylcysteine in hepatic injury due to acetaminophen intoxication in rats?en_US
dc.titleIs montelukast as effective as N-acetylcysteine in hepatic injury due to acetaminophen intoxication in rats?
dc.typeArticleen_US

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