The profile of the epidermal growth factor system in rat endometrium during postpartum involution period

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dc.contributor.authorAlan, Emel
dc.contributor.authorLiman, Narin
dc.contributor.authorSagsoz, Hakan
dc.date.accessioned2024-04-24T16:02:26Z
dc.date.available2024-04-24T16:02:26Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe epidermal growth factor (EGF) plays a crucial role in the control of uterine cell proliferation, growth and differentiation. This study was designed to investigate the spatiotemporal expression pattern and localization of the EGF receptor/ligand system during the process of uterine involution using immunohistochemistry. Our results indicated that the expression of the ErbB/HER receptors and their ligands varied with structural changes in the uterus at different days of involution. Supranuclear punctate ErbB1 immunostaining was observed in the luminal and glandular epithelial cells and endometrial fibroblasts. Moderate ErbB2/HER2 immunoreactivity was observed in the lateral membrane and cytoplasm of the epithelial cells on the 1st, 3rd and 5th days and was decreased on the other days of involution. The amount of nuclear and cytoplasmic ErbB3/HER3 and ErbB4/HER4 immunostaining remained constant throughout the postpartum period. The EGF immunoreaction was weak in the luminal and glandular epithelium throughout the involution period. Although the cytoplasmic AREG immunoreactivity in the glandular epithelium was stronger on the 1st and 3rd days compared with the other days of involution, NRG1 immunostaining was weak on the 1st and 3rd days and was moderate in the apical cytoplasm on the 10th and 15th days of involution. The macrophages displayed strong cytoplasmic immunoreactivity for ErbB3/HER3, ErbB4/HER4, EGF, AREG and NRG. Strong, moderate and weak immunostaining for ErbB2/HER2, ErbB4/HER4 and other proteins (ErbB1, ErbB3, AREG and NRG), respectively, was present in the myometrial smooth muscle cells. These findings support the hypothesis that the EGFsystem plays a role in the development of various physiological changes associated with uterine involution.en_US
dc.description.sponsorshipScientific Research Council of Erciyes University [TSA-12-3865]en_US
dc.description.sponsorshipThis study was financially supported by Scientific Research Council of Erciyes University (Project No: TSA-12-3865).en_US
dc.identifier.doi10.1007/s11259-015-9633-6
dc.identifier.endpage135en_US
dc.identifier.issn0165-7380
dc.identifier.issn1573-7446
dc.identifier.issue2en_US
dc.identifier.pmid25754972
dc.identifier.scopus2-s2.0-84937580876
dc.identifier.scopusqualityQ2
dc.identifier.startpage115en_US
dc.identifier.urihttps://doi.org/10.1007/s11259-015-9633-6
dc.identifier.urihttps://hdl.handle.net/11468/14788
dc.identifier.volume39en_US
dc.identifier.wosWOS:000354323900004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofVeterinary Research Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpidermal Growth Factor Receptorsen_US
dc.subjectLigandsen_US
dc.subjectPostpartumen_US
dc.subjectRaten_US
dc.subjectUterusen_US
dc.titleThe profile of the epidermal growth factor system in rat endometrium during postpartum involution perioden_US
dc.titleThe profile of the epidermal growth factor system in rat endometrium during postpartum involution period
dc.typeArticleen_US

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