Reduced PON1 enzymatic activity and increased lipid hydroperoxide levels that point out oxidative stress in generalized anxiety disorder

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dc.contributor.authorBulut, Mahmut
dc.contributor.authorSelek, Salih
dc.contributor.authorBez, Yasin
dc.contributor.authorKarababa, Ibrahim Fatih
dc.contributor.authorKaya, Mehmet Cemal
dc.contributor.authorGunes, Mehmet
dc.contributor.authorEmhan, Ali
dc.date.accessioned2024-04-24T16:14:59Z
dc.date.available2024-04-24T16:14:59Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn recent years, there has been an increasing focus on generalized anxiety disorder (GAD) which is one of the most prevalent mental disorders in general population. Psychological, genetic, neurobiological, and neurochemical factors are believed to play role in the etiopathogenesis of GAD. The role of oxidative stress, as a neurochemical cause, in various anxiety disorders has been studied in recent years; however, it has not been thoroughly studied in GAD, yet. In this paper, we aimed to evaluate the serum levels of lipid hydroperoxide (LOOH), paraoxonase, and arylesterase in GAD patients without any co-morbid psychiatric disorders and investigate their diagnostic performance. Blood samples were collected from 40 GAD patients and 40 healthy control subjects to measure their serum LOON levels, arylesterase and paraoxonase activities. Obtained results have been compared between groups and receiver operating characteristic (ROC) curve has been drawn for diagnostic performance of measured biochemical markers. Positive and negative predictive values have been estimated where appropriate. Mean LOOH level of the GAD patients was significantly higher than that of control subjects (t=-549, p<0.001), whereas, mean paraoxonase activity was lower in these patients (t=3.056, p=003), GAD could be predicted for LOON level over 7.740 mu mol/l with 92.5% positive predictive value and 92% negative predictive value. Increased LOON level and decreased paraoxonase activity of GAD patients may suggest increased lipid peroxidation and oxidative stress in these patients. LOON levels may be a state marker for diagnosing GAD. (C) 2013 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.jad.2013.03.011
dc.identifier.endpage833en_US
dc.identifier.issn0165-0327
dc.identifier.issn1573-2517
dc.identifier.issue3en_US
dc.identifier.pmid23706841
dc.identifier.scopus2-s2.0-84888387957
dc.identifier.scopusqualityQ1
dc.identifier.startpage829en_US
dc.identifier.urihttps://doi.org/10.1016/j.jad.2013.03.011
dc.identifier.urihttps://hdl.handle.net/11468/15567
dc.identifier.volume150en_US
dc.identifier.wosWOS:000324038000016
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Affective Disorders
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGeneralized Anxiety Disorderen_US
dc.subjectOxidative Stressen_US
dc.subjectParaoxonase/Arylesteraseen_US
dc.subjectLipid Hydroperoxideen_US
dc.subjectDiagnostic Performanceen_US
dc.titleReduced PON1 enzymatic activity and increased lipid hydroperoxide levels that point out oxidative stress in generalized anxiety disorderen_US
dc.titleReduced PON1 enzymatic activity and increased lipid hydroperoxide levels that point out oxidative stress in generalized anxiety disorder
dc.typeArticleen_US

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