The role of the heart-type fatty acid binding protein in the early diagnosis of acute coronary syndrome and its comparison with troponin I and creatine kinase-MB isoform

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dc.contributor.authorOrak, Murat
dc.contributor.authorUstundag, Mehmet
dc.contributor.authorGuloglu, Cahfer
dc.contributor.authorOzhasenekler, Ayhan
dc.contributor.authorAlyan, Omer
dc.contributor.authorKale, Ebru
dc.date.accessioned2024-04-24T16:10:43Z
dc.date.available2024-04-24T16:10:43Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: The aim of this study was to research the effectiveness of the heart-type fatty acid binding protein (H-FABP) in the early diagnosis of acute coronary syndrome (ACS) in patients admitted to emergency service (ES) within 6 hours of onset of chest pain. Equipment and Method: A total of 83 patients admitted with chest pain to our ES were included in this study. The patients were divided into 2 groups: those with a diagnosed ACS and those diagnosed with non cardiac-related chest pain. Patients were also were divided into 2 groups according to the time of admission: those admitted within 0 to 3 hours and 3 to 6 hours of onset of chest pain. Peripheral venous blood samples were obtained from all patients for H-FABP, troponin I, and creatine kinase-MB (CK-MB) serum concentration measurements. Results: Of a total of 83 patients, 21.6% (n = 18) were in the control group and 78.3% (n = 65) were in the ACS group. The average H-FABP value for the patients in the control group was 0.86 +/- 0.54 ng/mL. When the ACS and control groups were compared in means of cardiac markers for CK-MB (P = .000) and H-FABP (P = .000), there was a statistically significant difference, whereas no difference was observed for troponin I (P = .013). In the ACS group, H-FABP sensitivity for diagnosis was found to be 98% and specificity was 71%; CK-MB sensitivity was 86% and specificity was 52%; and troponin 1 sensitivity was 77% and specificity was 20%. Conclusions: For patients admitted with chest pain to ES, H-FABP was found to be more sensitive and specific than troponin I and CK-MB in the early diagnosis of ACS. (C) 2010 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipBoard of Scientific Research Projectsen_US
dc.description.sponsorshipThis study was carried out with the financial support of the Board of Scientific Research Projects and approval of the Directorate of the Board of Ethics of the Faculty of Medicine, Dicle University, Turkey.en_US
dc.identifier.doi10.1016/j.ajem.2009.05.012
dc.identifier.endpage896en_US
dc.identifier.issn0735-6757
dc.identifier.issn1532-8171
dc.identifier.issue8en_US
dc.identifier.pmid20825920
dc.identifier.scopus2-s2.0-77957326346
dc.identifier.scopusqualityQ1
dc.identifier.startpage891en_US
dc.identifier.urihttps://doi.org/10.1016/j.ajem.2009.05.012
dc.identifier.urihttps://hdl.handle.net/11468/15066
dc.identifier.volume28en_US
dc.identifier.wosWOS:000282669300009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofAmerican Journal of Emergency Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleThe role of the heart-type fatty acid binding protein in the early diagnosis of acute coronary syndrome and its comparison with troponin I and creatine kinase-MB isoformen_US
dc.titleThe role of the heart-type fatty acid binding protein in the early diagnosis of acute coronary syndrome and its comparison with troponin I and creatine kinase-MB isoform
dc.typeArticleen_US

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