Protective effects of caffeic acid phenethyl ester on isoniazid and rifampicin-induced hepatic and pancreatic injury

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dc.contributor.authorTürkçü, G.
dc.contributor.authorAvcı, Y.
dc.contributor.authorEvliyaoğlu, O.
dc.contributor.authorGökalp, O.
dc.contributor.authorGümüş, M.
dc.contributor.authorTanrıkulu, A. C.
dc.contributor.authorAbakay, A.
dc.contributor.authorBüyükbayram, H.
dc.contributor.authorFırat, U.
dc.date.accessioned2022-12-21T11:44:25Z
dc.date.available2022-12-21T11:44:25Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalıen_US
dc.description.abstractObjective: To investigate the protective effects of caffeic acid phenethyl ester (CAPE) against isoniazid (INH)- and rifampicin (RFP)-induced hepatic and pancreatic damage. Methods: Eighty adult rats were randomly divided into eight groups: control, INH, RFP, INII+RFP, INII+CAPE, RFP+CAPE, INII+RFP+CAPE, and CAPE. Both _MI and RFP were orally administered for 30 days at a dose of 50 mg/kg/day. Caffeic acid phenethyl ester was intraperitoneally injected for 30 days (10 mu mol/kg). Blood samples, hepatic and pancreatic tissues were obtained on day 30. Results: Total oxidant status levels were significantly higher in MI and/or RFP-treated groups than those of control and CAPE groups, while total antioxidant status and paraoxonase levels were significantly reduced in INH-RFP groups compared with the group receiving CAPE. Histopathological deterioration was observed in RFP and INH groups in pancreatic and hepatic tissue. However, significant amelioration was observed in CAPE-treated groups. Conclusion: Our findings suggest that CAPE may be a promising agent to prevent the side effects of INH and RFP treatment on hepatic and pancreatic tissues.en_US
dc.identifier.citationTürkçü, G., Avcı, Y., Evliyaoğlu, O., Gökalp, O., Gümüş, M., Tanrıkulu, A.C. ve diğerleri. (2021). Protective effects of caffeic acid phenethyl ester on isoniazid and rifampicin-induced hepatic and pancreatic injury. West Indian Medical Journal, 69(5), 350-355.en_US
dc.identifier.doi10.7727/wimj.2015.561
dc.identifier.endpage355en_US
dc.identifier.issn2309-5830
dc.identifier.issn0043-3144
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85122076693
dc.identifier.scopusqualityQ4
dc.identifier.startpage350en_US
dc.identifier.urihttps://www.mona.uwi.edu/fms/wimj/article/2815
dc.identifier.urihttps://hdl.handle.net/11468/11096
dc.identifier.volume69en_US
dc.identifier.wosWOS:000719641000016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorTürkçü, G.
dc.institutionauthorAvcı, Y.
dc.institutionauthorEvliyaoğlu, O.
dc.institutionauthorGökalp, O.
dc.institutionauthorGümüş, M.
dc.institutionauthorTanrıkulu, A.C.
dc.institutionauthorAbakay, A.
dc.institutionauthorBüyükbayram, H.
dc.institutionauthorFırat, U.
dc.language.isoenen_US
dc.publisherUniv West Indies Faculty Medical Sciencesen_US
dc.relation.ispartofWest Indian Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCaffeic acid phenethyl esteren_US
dc.subjectIsoniaziden_US
dc.subjectLiveren_US
dc.subjectPancreasen_US
dc.subjectRifampicinen_US
dc.titleProtective effects of caffeic acid phenethyl ester on isoniazid and rifampicin-induced hepatic and pancreatic injuryen_US
dc.titleProtective effects of caffeic acid phenethyl ester on isoniazid and rifampicin-induced hepatic and pancreatic injury
dc.typeArticleen_US

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