Protective effects of caffeic acid phenethyl ester on isoniazid and rifampicin-induced hepatic and pancreatic injury
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Univ West Indies Faculty Medical Sciences
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To investigate the protective effects of caffeic acid phenethyl ester (CAPE) against isoniazid (INH)- and rifampicin (RFP)-induced hepatic and pancreatic damage.
Methods: Eighty adult rats were randomly divided into eight groups: control, INH, RFP, INII+RFP, INII+CAPE, RFP+CAPE, INII+RFP+CAPE, and CAPE. Both _MI and RFP were orally administered for 30 days at a dose of 50 mg/kg/day. Caffeic acid phenethyl ester was intraperitoneally injected for 30 days (10 mu mol/kg). Blood samples, hepatic and pancreatic tissues were obtained on day 30.
Results: Total oxidant status levels were significantly higher in MI and/or RFP-treated groups than those of control and CAPE groups, while total antioxidant status and paraoxonase levels were significantly reduced in INH-RFP groups compared with the group receiving CAPE.
Histopathological deterioration was observed in RFP and INH groups in pancreatic and hepatic tissue. However, significant amelioration was observed in CAPE-treated groups.
Conclusion: Our findings suggest that CAPE may be a promising agent to prevent the side effects of INH and RFP treatment on hepatic and pancreatic tissues.
Açıklama
Anahtar Kelimeler
Caffeic acid phenethyl ester, Isoniazid, Liver, Pancreas, Rifampicin
Kaynak
West Indian Medical Journal
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
69
Sayı
5
Künye
Türkçü, G., Avcı, Y., Evliyaoğlu, O., Gökalp, O., Gümüş, M., Tanrıkulu, A.C. ve diğerleri. (2021). Protective effects of caffeic acid phenethyl ester on isoniazid and rifampicin-induced hepatic and pancreatic injury. West Indian Medical Journal, 69(5), 350-355.
