Eight-day methotrexate/folinic acid regime as single agent chemotherapy for low-risk gestational trophoblastic neoplasia: A retrospective study

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dc.authorid0000-0001-8609-3049en_US
dc.authorid0000-0001-7634-3008en_US
dc.authorid0000-0002-7095-9482en_US
dc.authorid0000-0003-2397-3924en_US
dc.authorid0000-0003-4281-1226en_US
dc.authorid0000-0003-0956-1050en_US
dc.authorid0000-0001-7328-4188en_US
dc.contributor.authorAkgöl, Sedat
dc.contributor.authorOğlak, Süleyman Cemil
dc.contributor.authorTunç, Şeyhmus
dc.contributor.authorKahramanoğlu, Özge
dc.contributor.authorÖlmez, Fatma
dc.contributor.authorKahramanoğlu, İlker
dc.contributor.authorBudak, Mehmet Şükrü
dc.date.accessioned2023-07-06T12:01:59Z
dc.date.available2023-07-06T12:01:59Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalıen_US
dc.description.abstractObjective: To evaluate the 8-day methotrexate (MTX)/folinic acid (FA) as a first-line chemotherapy regimen treatment in terms of complete regression of disease in women with low-risk gestational trophoblastic neoplasia (GTN). Material and Methods: All patients with low-risk GTN treated with an 8-day MTX/FA regimen were retrospectively included in the study. International Federation of Obstetrics and Gynecology and the modified World Health Organization Prognostic Scoring System were used to classify the risk of GTN. All women received diagnostic imaging evaluation before starting the treatment. The same MTX/FA regime was used repeating as a two-week cycle until normalization of the beta-human chorionic gonadotropin (ß-HCG), thus monthly ß-HCG follow-up was scheduled for up to 1 year. Results: Successful treatment was achieved in 56/66 (84.8%) patients. Nine (13.6%) women had resistance and 1 (1.6%) toxicity. The resistance patients were successfully treated with EMA-CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine) protocol, whereas the patient who showed toxicity to the MTX/FA regime was successfully treated with actinomycin-D. Conclusion: Eight-day MTX/FA regime could be useful in low-risk GTN patients with good security margins. The toxicity rates in this protocol were determined as quite low. All resistance was treated successfully with the EMA-CO protocol.en_US
dc.identifier.citationAkgöl, S., Oğlak, S. C., Tunç, Ş., Kahramanoğlu, Ö., Ölmez, F., Kahramanoğlu, İ. ve diğerleri. (2022). Eight-day methotrexate/folinic acid regime as single agent chemotherapy for low-risk gestational trophoblastic neoplasia: A retrospective study. Journal of Clinical Obstetrics & Gynecology, 32(1), 1-6.en_US
dc.identifier.doi10.5336/jcog.2021-87522
dc.identifier.endpage6en_US
dc.identifier.issn2619-9467
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85128867207
dc.identifier.scopusqualityQ4
dc.identifier.startpage1en_US
dc.identifier.trdizinid524055
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/524055
dc.identifier.urihttps://hdl.handle.net/11468/12205
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/524055
dc.identifier.volume32en_US
dc.identifier.wosWOS:000871242300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorBudak, Mehmet Şükrü
dc.language.isoenen_US
dc.publisherTürkiye Klinikleri Yayınevien_US
dc.relation.ispartofJournal of Clinical Obstetrics & Gynecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGestational trophoblastic diseaseen_US
dc.subjectDrug therapyen_US
dc.subjectMethotrexateen_US
dc.titleEight-day methotrexate/folinic acid regime as single agent chemotherapy for low-risk gestational trophoblastic neoplasia: A retrospective studyen_US
dc.titleEight-day methotrexate/folinic acid regime as single agent chemotherapy for low-risk gestational trophoblastic neoplasia: A retrospective study
dc.typeArticleen_US

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