Expression and localisation of epidermal growth factor receptors and their ligands in the lower genital tract of cycling cows

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dc.contributor.authorSagsoz, Hakan
dc.contributor.authorLiman, Narin
dc.contributor.authorSaruhan, Berna Guney
dc.contributor.authorAkbalik, Mehmet E.
dc.contributor.authorKetani, Muzaffer A.
dc.contributor.authorTopaloglu, Ugur
dc.date.accessioned2024-04-24T16:24:13Z
dc.date.available2024-04-24T16:24:13Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe epidermal growth factor receptor (ErbB) family and its ligands are essential for the regulation of multiple cellular processes required for mammalian reproduction. The objectives of this study were to investigate the expression and localisation of ErbB subtypes (ErbB1-4) and selected ligands, namely epidermal growth factor (EGF), amphiregulin (AREG) and neuregulin (NRG), in the cervix and vagina of cycling cows and to determine possible steroid hormone-dependence of their expression using immunohistochemistry. All four ErbBs and EGF, AREG and NRG proteins were found to be localised in the nucleus and cytoplasm of different cells in the cervix and vagina, and their expression differed during the oestrous cycle. During the follicular phase, in both the cervix and vagina, ErbB1, ErbB2, ErbB3, ErbB4 and EGF expression was higher in the luminal epithelium (LE) than in stromal and smooth muscle (SM) cells (P<0.05). During the luteal phase, the expression of ErbB1, ErbB3 and EGF in the LE was significantly different from that in stromal and SM cells in the cervix, whereas the expression of EGF and AREG differed in the vagina compared to the cervix (P<0.05). Throughout the oestrous cycle, in both the cervix and vagina, although ErbB2/human epidermal growth factor receptor 2 expression in the LE and SM cells was significantly higher than in the stromal cells (P<0.05), NRG expression was similar in the LE, stromal and SM cells (P>0.05). Overall, these results suggest that all four ErbBs and the EGF, AREG and NRG proteins may collectively contribute to several cellular processes in the bovine cervix and vagina during the oestrous cycle.en_US
dc.identifier.doi10.1071/RD18179
dc.identifier.endpage1706en_US
dc.identifier.issn1031-3613
dc.identifier.issn1448-5990
dc.identifier.issue11en_US
dc.identifier.pmid31270009
dc.identifier.scopus2-s2.0-85068562256
dc.identifier.scopusqualityQ2
dc.identifier.startpage1692en_US
dc.identifier.urihttps://doi.org/10.1071/RD18179
dc.identifier.urihttps://hdl.handle.net/11468/16591
dc.identifier.volume31en_US
dc.identifier.wosWOS:000489057300006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherCsiro Publishingen_US
dc.relation.ispartofReproduction Fertility and Development
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectErbb3en_US
dc.subjectErbb4en_US
dc.titleExpression and localisation of epidermal growth factor receptors and their ligands in the lower genital tract of cycling cowsen_US
dc.titleExpression and localisation of epidermal growth factor receptors and their ligands in the lower genital tract of cycling cows
dc.typeArticleen_US

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