TOX, TWIST1, STAT4, and SATB1 protein expressions in early-stage mycosis fungoides

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dc.authorid0000-0002-1536-6035en_US
dc.authorid0000-0002-0645-8755en_US
dc.contributor.authorÖrnek, Sinem
dc.contributor.authorÖzekinci, Selver
dc.contributor.authorIpin, Tuğba
dc.contributor.authorKocatürk, Emek
dc.date.accessioned2024-04-15T11:51:48Z
dc.date.available2024-04-15T11:51:48Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalıen_US
dc.description.abstractBackground: Diagnosis of early mycosis fungoides (eMF) is challenging and often delayed as many of its clinical and histopathologic features may mimic various benign inflammatory dermatoses (BIDs). The products of the thymocyte selection-associated high mobility group box (TOX), twist family BHLH transcription factor 1 (TWIST1), signal transducer and activator of transcription 4 (STAT4), and special AT-rich sequence-binding protein 1 (SATB1) genes function as transcription factors and are involved in the pathogenesis of MF. Objectives: We aim to determine the diagnostic value of TOX, TWIST1, STAT4, and SATB1 protein expressions in eMF. Methods: This non-randomized, controlled, prospective analytic study was conducted by performing immunohistochemistry staining with TOX, TWIST1, STAT4, and SATB1 polyclonal antibodies in lesional skin biopsies of eMF and BID patients. Nuclear staining of lymphocytes was compared between eMF and BIDs, and the capacity of these antibodies to predict eMF was determined. Results: Immunostainings with anti-TWIST1 showed an increase in protein expression (p = 0.003) and showed a decrease with anti-SATB1 antibodies in eMF compared to BIDs (p = 0.005) while anti-TOX and anti-STAT4 antibodies did not exhibit significant differences (p = 0.384; p = 0.150). Receiver operating characteristic analysis showed that immunohistochemical evaluations of TWIST1 and SATB1 protein expressions can differentiate eMF (area under the curve [AUC]: 0.728, 95% confidence interval [CI]: 0.605–0.851, p = 0.002; AUC: 0.686, 95% CI: 0.565–0.807, p = 0.013). Conclusions: TWIST1 and SATB1 are potential diagnostic markers for the histologic diagnosis of eMF.en_US
dc.identifier.citationÖrnek, S., Özekinci, S., Ipin, T. ve Kocatürk, E. (2024). TOX, TWIST1, STAT4, and SATB1 protein expressions in early-stage mycosis fungoides. Journal of Cutaneous Pathology, 51(3), 232-238.en_US
dc.identifier.doi10.1111/cup.14557
dc.identifier.endpage238en_US
dc.identifier.issn0303-6987
dc.identifier.issue3en_US
dc.identifier.pmid37932931
dc.identifier.scopus2-s2.0-85176138244
dc.identifier.scopusqualityQ2
dc.identifier.startpage232en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1111/cup.14557
dc.identifier.urihttps://hdl.handle.net/11468/13866
dc.identifier.volume51en_US
dc.identifier.wosWOS:001098958100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzekinci, Selver
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofJournal of Cutaneous Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCutaneous T-cell lymphomaen_US
dc.subjectDiagnostic biomarkeren_US
dc.subjectMycosis fungoidesen_US
dc.subjectSATB1en_US
dc.subjectSTAT4en_US
dc.subjectTOXen_US
dc.subjectTWIST1en_US
dc.titleTOX, TWIST1, STAT4, and SATB1 protein expressions in early-stage mycosis fungoidesen_US
dc.titleTOX, TWIST1, STAT4, and SATB1 protein expressions in early-stage mycosis fungoides
dc.typeArticleen_US

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