Immunohistochemical and Histopathological Changes in the Skin of Rats After Maneb Application

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dc.contributor.authorSula, Bilal
dc.contributor.authorEkinci, Cenap
dc.contributor.authorUcak, Haydar
dc.contributor.authorUcmak, Derya
dc.contributor.authorAkkurt, Zeynep Meltem
dc.contributor.authorYavuz, Dilek
dc.contributor.authorArica, Mustafa
dc.date.accessioned2024-04-24T17:37:31Z
dc.date.available2024-04-24T17:37:31Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To determine the immunohistochemical and histo pathological changes in facial skin after exposure to maneb (manganese ethylene bisdithiocarbamate), a fungicidal dithiocarbamate pesticide. STUDY DESIGN: In the experimental group maneb was administered by inhalation to 10 male Wistar albino rats for 5 days each week for 3 weeks. As a biological control, the control group (n=10) received distilled water by spray for the same time period. The experiment was terminated after 3 weeks. Sections of rat facial skin were examined histopathologically. RESULTS: In the experimental group, microscopic examination of facial skin revealed degeneration of the epidermis, detection of mild inflammatory reaction, and vascular dilation in the connective tissue. Hair follicles and degenerative changes were observed in the deeper parts. In the experimental group, dilation of the blood vessels in the dermis and hemorrhage were supported by an increase in CD34 expression. In addition, a reduction in the number of melanocytes (hypopigmentation) was observed in the hair follicles and epidermis, along with a decrease in the expression of CD117. CONCLUSION: Epidermal degeneration, intradermal cell infiltration, vascular changes, and reduction in the number of melanocytes in the follicle and content of cytokeratin in both the epidermis and hair follicle ker-atinocytes were detected after maneb application. These findings may have important implications in the association with main signaling pathways, including keratinocyte proliferation and differentiation. Disruption of these pathways may cause some dermatoses.en_US
dc.identifier.endpage329en_US
dc.identifier.issn0884-6812
dc.identifier.issue6en_US
dc.identifier.pmid25803990
dc.identifier.scopus2-s2.0-84920266396
dc.identifier.scopusqualityQ4
dc.identifier.startpage324en_US
dc.identifier.urihttps://hdl.handle.net/11468/20981
dc.identifier.volume36en_US
dc.identifier.wosWOS:000349428300004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCd34 Antigenen_US
dc.subjectCd117 Antigenen_US
dc.subjectEthylenebisdithiocarbamate Manganeseen_US
dc.subjectIndustrial Fungicidesen_US
dc.subjectManeben_US
dc.subjectRatsen_US
dc.subjectLaboratoryen_US
dc.subjectSkinen_US
dc.titleImmunohistochemical and Histopathological Changes in the Skin of Rats After Maneb Applicationen_US
dc.titleImmunohistochemical and Histopathological Changes in the Skin of Rats After Maneb Application
dc.typeArticleen_US

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