The hepatoprotective effect of coumarin and coumarin derivates on carbon tetrachloride-induced hepatic injury by antioxidative activities in rats

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dc.contributor.authorAtmaca, Mukadder
dc.contributor.authorBilgin, Hakki Murat
dc.contributor.authorObay, Basra Deniz
dc.contributor.authorDiken, Huda
dc.contributor.authorKelle, Mustafa
dc.contributor.authorKale, Ebru
dc.date.accessioned2024-04-24T16:02:51Z
dc.date.available2024-04-24T16:02:51Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractCoumarins are a vast group of natural compounds and some of them possess antioxidant activities. The comparison of the antioxidant activity of some coumarins with various chemical molecular structure has not been investigated in previous studies. Therefore, this study was aimed to investigate the hepatoprotective effect against carbon tetrachloride (CCl4) -induced hepatic injury by coumarin (1,2-benzopyrone) and coumarin derivatives, esculetin (6,7-dihydroxycoumarin), scoparone (6,7-dimethoxycoumarin), and 4-methylumbelliferone (7-hyroxy-4-methyl) in male Sprague-Dawley rats. Product of lipid peroxidation, malondialdehyde (MDA), activities of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) were evaluated for oxidative stress in hepatic injury. Gamma glutamyl transpeptidase (GGT), lactate dehydrogenase (LDH) were detected in plasma as a biomarker of hepatic injury. Significantly elevated levels of MDA and lowered levels of SOD and CAT activities were observed in liver of rats exposed to CCl4, when compared to control values. Similarly, administration of CCl4 increased LDH and GGT levels in serum. Pre-treatment of rats with esculetin (35 mg kg(-1), orally) and scoparone (35 mg kg(-1), orally) significantly prevented CCl4-induced decrease in MDA levels and increase in SOD and CAT, whereas 4-methylumbelliferone (35 mg kg(-1)) and coumarin (30 mg kg(-1)) had no effect against CCl4-induced rise in serum enzymes. Esculetin and scoparone also showed protective properties as was evidenced in reduced LDH and GGT levels in serum. The results of this study indicate that the chemical structures of coumarins play an important role in the prevention of oxidative stress.en_US
dc.description.sponsorshipDicle University [DUAPK 03-TF-42]en_US
dc.description.sponsorshipFinancial support for this study was provided by Dicle University, administered through the Research Project Unit (Project number: DUAPK 03-TF-42).en_US
dc.identifier.doi10.1007/s13105-011-0103-5
dc.identifier.endpage576en_US
dc.identifier.issn1138-7548
dc.identifier.issn1877-8755
dc.identifier.issue4en_US
dc.identifier.pmid21656273
dc.identifier.scopus2-s2.0-85027932918
dc.identifier.scopusqualityQ2
dc.identifier.startpage569en_US
dc.identifier.urihttps://doi.org/10.1007/s13105-011-0103-5
dc.identifier.urihttps://hdl.handle.net/11468/14933
dc.identifier.volume67en_US
dc.identifier.wosWOS:000296518500008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Physiology and Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCcl4-Induced Hepatotoxicityen_US
dc.subjectAntioxidanten_US
dc.subjectHepatoprotectionen_US
dc.subjectCoumarinsen_US
dc.titleThe hepatoprotective effect of coumarin and coumarin derivates on carbon tetrachloride-induced hepatic injury by antioxidative activities in ratsen_US
dc.titleThe hepatoprotective effect of coumarin and coumarin derivates on carbon tetrachloride-induced hepatic injury by antioxidative activities in rats
dc.typeArticleen_US

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