The effects of high serum growth hormone and IGF-1 levels on bone mineral density in acromegaly

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dc.contributor.authorTuzcu, S.
dc.contributor.authorDurmaz, S. A.
dc.contributor.authorCarlioglu, A.
dc.contributor.authorDemircan, Z.
dc.contributor.authorTuzcu, A.
dc.contributor.authorBeyaz, C.
dc.contributor.authorTay, A.
dc.date.accessioned2024-04-24T16:00:14Z
dc.date.available2024-04-24T16:00:14Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective. Growth hormone (GH) and insulinlike growth factor-1 (IGF-1) play a major role in bone homeostasis. In this study, we aimed to assess bone mineral density (BMD) in active acromegaly. Materials andmethods. A total of 29 patients with active acromegaly (age 46.10 +/- 13.27 years; body mass index [BMI]: 29.51 +/- 4.91 kg/m(2)) and 42 healthy individuals matched for age and BMI (age: 40.35 +/- 11.74 years; BMI: 28.18 +/- 7.35 kg/m(2)) were included in the study. BMD wasmeasured by DXA. Results. The mean levels of GH and IGF1 were found to be 12.61 +/- 11.34 ng/ml and 676.47 +/- 316.19 ng/ml in acromegaly, respectively, while the mean levels of GH and IGF-1 were found to be 0.59 +/- 0.81 ng/ml (p = 0.0001) and 178.17 +/- 57.11 ng/ml (p = 0.0001) in the control group, respectively. Only total hip t-score was determined to be significantly lower in acromegaly compared to the control group (p = 0.037). No significant differences were found between the other parameters in DXA and only a positive correlation was found between IGF-1 levels and L1-L4 BMD (r = 0.259, p = 0.029). Conclusions. Although GH and IGF-1 levels were increased in acromegalic patients, no significant difference was found in terms of vertebral BMD. Only hip t-scores were found to be lower in acromegalic patients, but this low hip t-score did not reach the osteopenic level. The positive correlation between IGF-1 and lumbar vertebral BMD suggested a more prominent effect of IGF-1 on BMD compared to GH.en_US
dc.identifier.doi10.1007/s00393-016-0171-6
dc.identifier.endpage722en_US
dc.identifier.issn0340-1855
dc.identifier.issn1435-1250
dc.identifier.issue8en_US
dc.identifier.pmid27766418
dc.identifier.scopus2-s2.0-84991759005
dc.identifier.scopusqualityQ3
dc.identifier.startpage716en_US
dc.identifier.urihttps://doi.org/10.1007/s00393-016-0171-6
dc.identifier.urihttps://hdl.handle.net/11468/14414
dc.identifier.volume76en_US
dc.identifier.wosWOS:000412168300014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofZeitschrift Fur Rheumatologie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcromegalyen_US
dc.subjectBone Mineral Densityen_US
dc.subjectInsulin Like Growth Factor-1 (Igf-1)en_US
dc.titleThe effects of high serum growth hormone and IGF-1 levels on bone mineral density in acromegalyen_US
dc.titleThe effects of high serum growth hormone and IGF-1 levels on bone mineral density in acromegaly
dc.typeArticleen_US

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