Prolidase, Matrix Metalloproteinases 1 and 13 Activity, Oxidative-Antioxidative Status as a Marker of Preterm Premature Rupture of Membranes and Chorioamnionitis in Maternal Vaginal Washing Fluids

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dc.contributor.authorSoydinc, Hatice Ender
dc.contributor.authorSak, Muhammet Erdal
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorEvsen, Mehmet Siddik
dc.contributor.authorTurgut, Abdulkadir
dc.contributor.authorOzler, Ali
dc.contributor.authorYildiz, Ismail
dc.date.accessioned2024-04-24T17:28:14Z
dc.date.available2024-04-24T17:28:14Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Etiology of premature preterm rupture of membranes (PPROM) is not yet completely known and chorioamnionitis is one of the most important complications of its. We aimed to evaluate whether prolidase, matrix metalloproteinases, oxidative-antioxidative status, and inflammation markers in vaginal washing fluid (VWF) were associated with etiology of PPROM and whether these markers could be used to predict chorioamnionitis in PPROM. Study Design: This prospective case control study enrolled fifty pregnant women with PPROM and 50 healthy pregnant women. The VWF samples were taken at the time of admission in the PPROM group and patients were followed for chorioamnionitis. Prolidase, matrix metalloproteinases, oxidative-antioxidative status, and inflammation markers in VWF were assayed. Results: VWF levels of prolidase, matrix metalloproteinases 1-13 (p<0.001), oxidative stress parameters, total oxidative stress (TOS) (p < 0.001) and oxidative stress index (OSI) (p = 0.002), and hs-CRP (p = 0.045) were significantly higher in the PPROM group than in the controls. Antioxidative status parameters, levels of paroxanase (PON-1) (p < 0.001) and total antioxidant capacity (TAC) (p < 0.001), were significantly lower in the PPROM group than in the controls. Mean VWF levels of prolidase (p < 0.001), metalloproteinases (p<0.05), and oxidative-antioxidative status parameters (p<0.05) were significantly different in women with versus women without chorioamnionitis in the PPROM group. Prolidase, MMP-13, TOS, TAC, and PON-1 were found as important predictors for chorioamnionitis in the PPROM group by the multivariate logistic regression analysis. When the ROC curve analysis for prolidase, MMP-13, TOS, TAC, and PON-1 were performed, all of them were statistically significant for area under the curve (areas under the curve were 0.94, 0.90, 0.80, 0.25, and 0.19, respectively). Conclusions: This study showed that collagen turnover mediators, especially prolidase, and increased oxidative stress are significantly associated with PPROM. Also, chorioamnionitis can be predicted with prolidase, MMP-13, TOS, TAC, and PON-1 in PPROM patients.en_US
dc.description.sponsorshipDicle University (DUBAB) [10-TF-57]en_US
dc.description.sponsorshipThis study was supported by Scientific Research and Project Coordinator (DUBAB, 10-TF-57) in Dicle University.en_US
dc.identifier.doi10.7150/ijms.4802
dc.identifier.endpage1351en_US
dc.identifier.issn1449-1907
dc.identifier.issue10en_US
dc.identifier.pmid23983595
dc.identifier.scopus2-s2.0-84882775192
dc.identifier.scopusqualityQ1
dc.identifier.startpage1344en_US
dc.identifier.urihttps://doi.org/10.7150/ijms.4802
dc.identifier.urihttps://hdl.handle.net/11468/20372
dc.identifier.volume10en_US
dc.identifier.wosWOS:000324411800012
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherIvyspring Int Publen_US
dc.relation.ispartofInternational Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPremature Preterm Rupture Of Membraneen_US
dc.subjectChorioamnionitisen_US
dc.subjectProlidaseen_US
dc.subjectMatrix Metalloproteinasesen_US
dc.subjectTotal Oxidative Statusen_US
dc.subjectTotal Antioxidative Capacityen_US
dc.subjectParaoxonase-1en_US
dc.subjectVaginal Washing Fluiden_US
dc.titleProlidase, Matrix Metalloproteinases 1 and 13 Activity, Oxidative-Antioxidative Status as a Marker of Preterm Premature Rupture of Membranes and Chorioamnionitis in Maternal Vaginal Washing Fluidsen_US
dc.titleProlidase, Matrix Metalloproteinases 1 and 13 Activity, Oxidative-Antioxidative Status as a Marker of Preterm Premature Rupture of Membranes and Chorioamnionitis in Maternal Vaginal Washing Fluids
dc.typeArticleen_US

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