Clarifying the Relationship Between ABO/Rhesus Blood Group Antigens and Upper Gastrointestinal Bleeding

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dc.contributor.authorBayan, Kadim
dc.contributor.authorTuzun, Yekta
dc.contributor.authorYilmaz, Serif
dc.contributor.authorDursun, Mehmet
dc.contributor.authorCanoruc, Fikri
dc.date.accessioned2024-04-24T16:02:08Z
dc.date.available2024-04-24T16:02:08Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground and Aim The relationship between blood group antigens and peptic ulcer disease has been widely evaluated in the past. Data concerning the same association with upper gastrointestinal bleeding are very limited. We aimed to evaluate this association and we thought it was worthwhile to try to determine whether these components take some part in this complication. Methods The study population consisted of 1,098 adults (364 patients and 734 volunteer blood donors as controls). Demographic features, comorbid illnesses, and use of aspirin/nonsteroidal anti-inflammatory drugs (NSAIDs) were recorded. Blood groups were examined by gel centrifugation method. We included only patients with bleeding from peptic ulcer disease and erosive gastropathy. Ulcers were classified by using Forrest's classification system in terms of rebleeding risk. Helicobacter pylori was examined by histology. Results The gender distribution was similar in both groups. The ABO blood group phenotype distribution in patients and controls (respectively) was as follows: 46.2% versus 34.9% for group O, 32.4% versus 39.5% for group A, 15.7% versus 18.4% for group B, and 5.8% versus 7.2% for group AB. Blood group O was found to have higher frequency in the patient group than in the control group (P = 0.004). Rh positivity was also higher in patients than in controls (P = 0.007). H. pylori positivity was similar between blood groups among patients. The rebleeding and mortality rates between blood groups were also similar. Conclusion ABO blood group O had an important role in patients with upper gastrointestinal bleeding. The impact of blood group on rebleeding and mortality may be a focus for further studies.en_US
dc.identifier.doi10.1007/s10620-008-0446-0
dc.identifier.endpage1034en_US
dc.identifier.issn0163-2116
dc.identifier.issn1573-2568
dc.identifier.issue5en_US
dc.identifier.pmid18716867
dc.identifier.scopus2-s2.0-63949086804
dc.identifier.scopusqualityQ1
dc.identifier.startpage1029en_US
dc.identifier.urihttps://doi.org/10.1007/s10620-008-0446-0
dc.identifier.urihttps://hdl.handle.net/11468/14646
dc.identifier.volume54en_US
dc.identifier.wosWOS:000264810100016
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofDigestive Diseases and Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBlood Groupsen_US
dc.subjectUpper Gastrointestinal Bleedingen_US
dc.titleClarifying the Relationship Between ABO/Rhesus Blood Group Antigens and Upper Gastrointestinal Bleedingen_US
dc.titleClarifying the Relationship Between ABO/Rhesus Blood Group Antigens and Upper Gastrointestinal Bleeding
dc.typeArticleen_US

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