Effect of a controlled-release chlorhexidine chip on clinical and microbiological parameters and prostaglandin E2 levels in gingival crevicular fluid

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dc.contributor.authorMizrak, Tansel
dc.contributor.authorGuncu, Guliz N.
dc.contributor.authorCaglayan, Feriha
dc.contributor.authorBalci, Tansel Ansal
dc.contributor.authorAktar, Gulseren Samanci
dc.contributor.authorIpek, Fikret
dc.date.accessioned2024-04-24T17:18:22Z
dc.date.available2024-04-24T17:18:22Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: The aim of the present study was to determine the effect of a chlorhexidine chip on crevicular prostaglandin E-2 (PGE(2)) levels and on the clinical and microbiological parameters of periodontitis when used as adjunctive therapy to scaling and root planing (SRP) in patients with chronic periodontitis. Methods: This randomized single-blind study was carried out in parallel design. The test group received SRP plus chlorhexidine chip, whereas the control group received SRP alone. Thirty-four subjects, aged 20 to 55 years, with chronic periodontitis were recruited. Clinical indices, microbiological samples, and gingival crevicular fluid (GCF) samples were evaluated at baseline and after 1, 3, and 6 months. Microbiological samples were evaluated under a light microscope. GCF PG2 levels were determined using radioimmunoassay. Results: Significant improvements could be found for all clinical variables in both groups over the study period. The mean changes in probing depth obtained by SRP plus chlorhexidine chip were greater than those obtained by the SRP alone group at 3 and 6 months. In the test group, there was also significant gain in clinical attachment level at 6 months. When data were combined from all groups, significant reductions in GCF PGE(2) levels and number of microorganisms were noted at all time points. However, in the test group, reduction was greater at 6 months for crevicular PGE(2) level and at 3 and 6 months for proportions of spirochetes. Conclusion: Based on the findings of this study, the chlorhexidine chip reduced GCF PGE(2) levels and had positive effects on clinical parameters and subgingival flora when used as adjunctive therapy to SRP in patients with chronic periodontitis.en_US
dc.identifier.doi10.1902/jop.2006.050105
dc.identifier.endpage443en_US
dc.identifier.issn0022-3492
dc.identifier.issn1943-3670
dc.identifier.issue3en_US
dc.identifier.pmid16512758
dc.identifier.scopus2-s2.0-33646341767
dc.identifier.scopusqualityQ1
dc.identifier.startpage437en_US
dc.identifier.urihttps://doi.org/10.1902/jop.2006.050105
dc.identifier.urihttps://hdl.handle.net/11468/18749
dc.identifier.volume77en_US
dc.identifier.wosWOS:000241878600013
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Periodontology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChlorhexidine/Therapeutic Useen_US
dc.subjectDrug Delivery Systemsen_US
dc.subjectGingival Crevicular Fluid/Analysisen_US
dc.subjectProstaglandin Een_US
dc.titleEffect of a controlled-release chlorhexidine chip on clinical and microbiological parameters and prostaglandin E2 levels in gingival crevicular fluiden_US
dc.titleEffect of a controlled-release chlorhexidine chip on clinical and microbiological parameters and prostaglandin E2 levels in gingival crevicular fluid
dc.typeArticleen_US

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