The protective effect of curcumin on ischemia-reperfusion injury in rat ovary

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dc.contributor.authorSak, Muhammet Erdal
dc.contributor.authorSoydinc, Hatice Ender
dc.contributor.authorSak, Sibel
dc.contributor.authorEvsen, Mehmet Siddik
dc.contributor.authorAlabalik, Ulas
dc.contributor.authorAkdemir, Fatih
dc.contributor.authorGul, Talip
dc.date.accessioned2024-04-24T16:14:55Z
dc.date.available2024-04-24T16:14:55Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: To evaluate the protective effects of curcumin in experimental ischemia and ischemia/reperfusion (I/R) injury of rat ovaries. Methods: Forty-eight female adult Wistar Albino rats were used. Rats divided into six groups and designed: Sham, Torsion, Detorsion, Sham + Curcumin, Torsion + Curcumin, and Detorsion + Curcumin. Except for the Sham and Sham + Curcumin group, all groups were performed to bilateral adnexal torsion for 3 h. Bilateral adnexal detorsion was implemented in the Detorsion and Detorsion + Curcumin groups. The injection of curcumin was intraperitoneally achieved 30 min before the sham, torsion and detorsion. Results: Total oxidant status levels (TOS), oxidative stress index (OSI) and histologic scores values of ovarian tissue were higher in the torsion and detorsion groups than the sham group (p < 0.05). There was a strong correlation between the total histologic scores of I/R injury and the OSI (r = 0.809, p < 0.001). By the use of curcumin, a significant decrease was established in the mean levels of oxidant markers and histopathologic scores of the ovarian tissues. Conclusions: Administration of curcumin is effective in reversing tissue damage induced by ischemia-reperfusion injury in ovarian torsion. (C) 2013 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijsu.2013.06.007
dc.identifier.endpage970en_US
dc.identifier.issn1743-9191
dc.identifier.issn1743-9159
dc.identifier.issue9en_US
dc.identifier.pmid23796447
dc.identifier.scopus2-s2.0-84887200588
dc.identifier.scopusqualityQ1
dc.identifier.startpage967en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijsu.2013.06.007
dc.identifier.urihttps://hdl.handle.net/11468/15523
dc.identifier.volume11en_US
dc.identifier.wosWOS:000326977200045
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofInternational Journal of Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdnexial Torsionen_US
dc.subjectCurcuminen_US
dc.subjectOxidative Stressen_US
dc.subjectRaten_US
dc.titleThe protective effect of curcumin on ischemia-reperfusion injury in rat ovaryen_US
dc.titleThe protective effect of curcumin on ischemia-reperfusion injury in rat ovary
dc.typeArticleen_US

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