Comprehensive phenolic profiling and biological evaluation of Centaurea glastifolia L. (Asteraceae)

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dc.authoridGOZCU, SEFA/0000-0002-0735-4229
dc.contributor.authorGozcu, Sefa
dc.contributor.authorAksit, Zeynep
dc.contributor.authorAydin, Ali
dc.contributor.authorYilmaz, Mustafa Abdullah
dc.contributor.authorSimsek, Samed
dc.date.accessioned2025-02-22T14:08:55Z
dc.date.available2025-02-22T14:08:55Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe present investigation focused on the comprehensive analysis of the phenolic profile of Centaurea glastifolia L. (Asteraceae) and the assessment of its diverse biological activities. Utilising LC-MS/MS, the phytochemical composition of the 70% methanol extract of Centaurea glastifolia (CG-ME) was thoroughly elucidated, revealing the presence of 30 distinct phytochemical compounds. Notably, major phenolic constituents identified in the extract included quinic acid, chlorogenic acid, luteolin-7-O-glucoside, kaempferol-3-O-glucoside, luteolin, and apigenin-7-O-glucoside. The antioxidant, antibacterial, antiproliferative, and cytotoxic activities of CG-ME were investigated. The CG-ME exhibited a moderate capacity for scavenging DPPH radicals (IC50: 50.05 +/- 1.58 mu g/mL) and FRAP (63.96 +/- 0.39 mg TE/g extract), indicating a moderate level of antioxidant activity. Moreover, CG-ME demonstrated significant antiproliferative effects (GI(50): 1.10 and 1.30 mu g/mL) on cancer cells (C6 and HTC cancer cell lines, respectively) while displaying low cytotoxicity towards normal cells (LC50: >1000 mu g/mL). In terms of antibacterial activity, CG-ME was found to be inactive against tested both Gram-positive and Gram-negative bacterial strains (MIC > 500 mu g/mL). The extracts had a promising antiproliferative effect on C6, HeLa, and HT29 cancer cell lines with a less cytotoxic effect (10.5-14.2%) against normal cells.en_US
dc.description.sponsorshipWe thank Professor Dr Ali Kandemir for the taxonomic description of the plant samples. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.en_US
dc.identifier.doi10.1080/14786419.2024.2403028
dc.identifier.issn1478-6419
dc.identifier.issn1478-6427
dc.identifier.pmid39267357en_US
dc.identifier.scopus2-s2.0-85204123685en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1080/14786419.2024.2403028
dc.identifier.urihttps://hdl.handle.net/11468/29714
dc.identifier.wosWOS:001311923000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNatural Product Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectCentaurea glastifolia Len_US
dc.subjectantiproliferativeen_US
dc.subjectantioxidanten_US
dc.subjectantibacterialen_US
dc.subjectLC-MS/MSen_US
dc.titleComprehensive phenolic profiling and biological evaluation of Centaurea glastifolia L. (Asteraceae)en_US
dc.typeArticleen_US

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