The effects of ellagic acid on the liver and remote organs' oxidative stress and structure after hepatic ischemia reperfusion injury caused by pringle maneuver in rats

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dc.contributor.authorKapan, M.
dc.contributor.authorGumus, M.
dc.contributor.authorOnder, A.
dc.contributor.authorFirat, U.
dc.contributor.authorBasarali, Kemal M.
dc.contributor.authorBoyuk, A.
dc.contributor.authorAliosmanoglu, F.
dc.date.accessioned2024-04-24T17:24:18Z
dc.date.available2024-04-24T17:24:18Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractIntroduction: We aimed to investigate the possible protective effects of ellagic acid (EA) on the liver and remote organs against the hepatic ischemia-reperfusion injury. Methods: Forty Wistar-Albino rats were divided into four groups each containing 10 rats. Group I with laparotomy only, Group II with laparatomy and ellagic acid application, Group III with hepatic ischemia-reperfusion and Group IV with hepatic ischemia-reperfusion and ellagic acid application. Hepatic ischemia was induced by pringle's manoeuvre for 30 minutes followed by 30 minutes reperfusion period. After induction of ischemia, EA was applied via oral gavage at a dose of 85 mg/kg. Blood samples were taken from the animals for biochemical analysis at 60th minute of the experiment in all groups. Simultaneously, liver, lung and kidney tissues were sampled for biochemical analyses and histopathological examinations. Results: The administration of EA reduced serum malonyldialdehid levels (p<0.05) and liver's oxidative stress index compared with the non-use EA groups (p<0.05). Although, ameliorated liver histopathological changes were seen in EA groups, these changes were not statistically significant (p>0.05). The use of EA did not exert significant protective effects against the effects of liver ischemia-reperfusion injury on the kidney and lung. Conclusion: In our experiments ellagic acid reduced the liver oxidative stress induced by ischemia-reperfusion injury. However, no significant histological improvement was found with EA. There were no significant protective effects on the remote organ injuries induced by ischemia-reperfusion (Tab. 3, Fig. 7, Ref. 37). Full Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2012_064
dc.identifier.endpage281en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue5en_US
dc.identifier.pmid22616584
dc.identifier.scopus2-s2.0-84871867737
dc.identifier.scopusqualityQ2
dc.identifier.startpage274en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2012_064
dc.identifier.urihttps://hdl.handle.net/11468/19591
dc.identifier.volume113en_US
dc.identifier.wosWOS:000304794900003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatic Ischemia Reperfusionen_US
dc.subjectEllagic Aciden_US
dc.subjectLiveren_US
dc.subjectRemote Organsen_US
dc.titleThe effects of ellagic acid on the liver and remote organs' oxidative stress and structure after hepatic ischemia reperfusion injury caused by pringle maneuver in ratsen_US
dc.titleThe effects of ellagic acid on the liver and remote organs' oxidative stress and structure after hepatic ischemia reperfusion injury caused by pringle maneuver in rats
dc.typeArticleen_US

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