A comprehensive analysis of 12 thrombophilic mutations and related parameters in patients with inflammatory bowel disease

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dc.contributor.authorYilmaz, Serif
dc.contributor.authorBayan, Kadim
dc.contributor.authorTuezuen, Yekta
dc.contributor.authorBatun, Sabri
dc.contributor.authorAltintas, Abdullah
dc.date.accessioned2024-04-24T16:02:20Z
dc.date.available2024-04-24T16:02:20Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground Possible association of inflammatory bowel disease (IBD) with the most common inherited prothrombotic conditions has been the focus of many investigations. Advance in modern molecular biology is expanding the thrombophilia evaluation steadily. We tried to put forward a comprehensive thrombophilic profile in IBD and to see the probable role of this profile in pathogenesis. Methods A total of 60 adults (33 patients and 27 healthy controls) were included. We used the CVD-StripAssay which is based on the reverse-hybridization principle to identify a total of 12 thrombophilic gene mutations: Factor V R506Q, Factor V H1299R, prothrombin G20210A, Factor XIII V34L, beta-Fibrinogen-455 G-A, PAI-1 4G/5G, platelet GPIIIa L33P, MTHFR C677T, MTHFR A1298C, ACE I/D, Apo B R3500Q and Apo E2/E3/E4, respectively. Besides, we evaluated many related blood parameters such as protein C, protein S, AT-III, IL-6, TNF-alpha, Apo-A1, Apo-B100, homocysteine (tHcy) etc. using commercially available assays. Results The frequencies of genetic polymorphisms were found to be statistically insignificant among patients and controls, except for three: Beta-Fibrinogen-455G-A, MTHFR A1298C and ACE-I/D. Two patients with a history of deep venous thrombosis had more than one polymorphism. Patients with MTHFR C677T and MTHFR A1298C gene mutations had a similar mean tHcy levels with controls. Patients with Apolipoprotein B R3500Q and Apolipoprotein E4 gene mutations had similar mean LDL-cholesterol levels. Mean total cholesterol and triglyceride levels were similar in patients and controls of Apo E2, E3, E4 alleles. Conclusion Predominantly, the presence of genetic mutations that predispose to hypercoagulable states does not appear to be in correlation with IBD. There was a statistical difference between the proportions of the mutated allele frequencies of Beta-Fibrinogen-455G-A, MTHFR A1298C and ACE-I/D in IBD.en_US
dc.identifier.doi10.1007/s11239-006-9032-5
dc.identifier.endpage212en_US
dc.identifier.issn0929-5305
dc.identifier.issn1573-742X
dc.identifier.issue3en_US
dc.identifier.pmid17111197
dc.identifier.scopus2-s2.0-33845252483
dc.identifier.scopusqualityQ1
dc.identifier.startpage205en_US
dc.identifier.urihttps://doi.org/10.1007/s11239-006-9032-5
dc.identifier.urihttps://hdl.handle.net/11468/14749
dc.identifier.volume22en_US
dc.identifier.wosWOS:000242627400008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Thrombosis and Thrombolysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInflammatory Bowel Diseaseen_US
dc.subjectThrombophilic Mutationsen_US
dc.titleA comprehensive analysis of 12 thrombophilic mutations and related parameters in patients with inflammatory bowel diseaseen_US
dc.titleA comprehensive analysis of 12 thrombophilic mutations and related parameters in patients with inflammatory bowel disease
dc.typeArticleen_US

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