Intraperitoneal curcumin decreased lung, renal and heart injury in abdominal aorta ischemia/reperfusion model in rat

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dc.contributor.authorAydin, Mehmet Salih
dc.contributor.authorCaliskan, Ahmet
dc.contributor.authorKocarslan, Aydemir
dc.contributor.authorKocarslan, Sezen
dc.contributor.authorYildiz, Ali
dc.contributor.authorGunay, Samil
dc.contributor.authorSavik, Emin
dc.date.accessioned2024-04-24T16:14:56Z
dc.date.available2024-04-24T16:14:56Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Previous studies have demonstrated that curcumin (CUR) has protective effects against ischemia reperfusion injury to various organs. We aimed to determine whether CUR has favorable effects on tissues and oxidative stress in abdominal aorta ischemia-reperfusion injury. Materials and methods: Thirty rats were divided into three groups as sham, control and treatment (CUR) group. Control and CUR groups underwent abdominal aorta ischemia for 60 min followed by a 120 min period of reperfusion. In the CUR group, CUR was given 5 min before reperfusion at a dose of 200 mg/kg via an intraperitoneal route. Total antioxidant capacity (TAC), total oxidative status (TOS), and oxidative stress index (OSI) in blood serum were measured, and lung, renal and heart tissue histopathology were evaluated with light microscopy. Results: TOS and OSI activity in blood samples were statistically decreased in sham and CUR groups compared to the control group (p < 0.001 for TOS and OSI). Renal, lung, heart injury scores of sham and CUR groups were statistically decreased compared to control group (p < 0.001 for all comparisons). Histopathological examination revealed less severe lesions in CUR group than in the control group. Conclusion: CUR administered intraperitoneally was effective in reducing oxidative stress and histopathologic injury in an acute abdominal aorta I/R rat model. (C) 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijsu.2014.04.013
dc.identifier.endpage605en_US
dc.identifier.issn1743-9191
dc.identifier.issn1743-9159
dc.identifier.issue6en_US
dc.identifier.pmid24815029
dc.identifier.scopus2-s2.0-84901953524
dc.identifier.scopusqualityQ1
dc.identifier.startpage601en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijsu.2014.04.013
dc.identifier.urihttps://hdl.handle.net/11468/15525
dc.identifier.volume12en_US
dc.identifier.wosWOS:000338926300008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInternational Journal of Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAbdominal Aortaen_US
dc.subjectIschemia Reperfusionen_US
dc.subjectCurcuminen_US
dc.subjectOxidative Statusen_US
dc.titleIntraperitoneal curcumin decreased lung, renal and heart injury in abdominal aorta ischemia/reperfusion model in raten_US
dc.titleIntraperitoneal curcumin decreased lung, renal and heart injury in abdominal aorta ischemia/reperfusion model in rat
dc.typeArticleen_US

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