Predictors of outcome in patients with tuberculous meningitis

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dc.contributor.authorHosoglu, S
dc.contributor.authorGeyik, MF
dc.contributor.authorBalik, I
dc.contributor.authorAygen, B
dc.contributor.authorErol, S
dc.contributor.authorAygencel, TG
dc.contributor.authorMert, A
dc.date.accessioned2024-04-24T17:37:48Z
dc.date.available2024-04-24T17:37:48Z
dc.date.issued2002
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To assess predictors of mortality and neurological sequelae in patients with tuberculous meningitis (TBM). METHODS: Patients with TBM treated at 12 university hospitals in Turkey between 1985 and 1997 were evaluated using a standardised protocol applied retrospectively. Variables associated with hospital mortality as well as with the presence of neurological sequelae at 6 months were determined using logistic regression models. RESULTS: Four hundred and thirty-four patients between the ages of 13 and 83 years (mean 33 years) were evaluated. Sixty-eight per cent of these patients presented with Medical Research Council Stage H or III. One hundred and one patients (23.3%) died and 67 (27%) of evaluable survivors had neurological sequelae. In multivariable analysis, convulsion (OR 3.3, 95%CI 1.2-9.0, P = 0.02), comatose mental status (OR 6.0, 95%CI 3.6-10.2, P = 0.01), and delayed or interrupted treatment (OR 5.1, 95%CI 2.4-11.2, P = 0.01) were shown to be predictors for mortality. The presence of extra-meningeal tuberculosis (OR 2.1, 95%CI 1.1-4.2, P = 0.035), cranial nerve palsy (OR 2.6, 95%CI 1.4-4.2, P = 0.01), hemiparesia/focal weakness (OR 9.3, 95%CI 3.8-22.6, P = 0.01), hemiplegia/multiple neurological deficit (OR 7.1, 95%CI 2.14-23.38, P = 0.01) and drowsiness (OR 4.2, 95%CI 2.04-8.82, P = 0.01) were independent predictors of neurological sequelae at 6 months following hospital discharge. CONCLUSION: The results of this study emphasise the importance of prompt and uninterrupted anti-tuberculosis therapy for tuberculous meningitis. The presence of seizures or coma on admission to hospital are important predictors for mortality, while the presence of focal neurological signs is a predictor for persistent neurological sequelae in survivors.en_US
dc.identifier.endpage70en_US
dc.identifier.issn1027-3719
dc.identifier.issn1815-7920
dc.identifier.issue1en_US
dc.identifier.pmid11931403
dc.identifier.scopus2-s2.0-0036196198
dc.identifier.scopusqualityQ2
dc.identifier.startpage64en_US
dc.identifier.urihttps://hdl.handle.net/11468/21187
dc.identifier.volume6en_US
dc.identifier.wosWOS:000174776100010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherInt Union Against Tuberculosis Lung Disease (I U A T L D)en_US
dc.relation.ispartofInternational Journal of Tuberculosis and Lung Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTuberculous Meningitisen_US
dc.subjectOutcomeen_US
dc.subjectIndependent Factorsen_US
dc.titlePredictors of outcome in patients with tuberculous meningitisen_US
dc.titlePredictors of outcome in patients with tuberculous meningitis
dc.typeArticleen_US

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