Serum myeloperoxidase levels in predicting the severity of stroke and mortality in acute ischemic stroke patients

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dc.contributor.authorTay, A.
dc.contributor.authorTamam, Y.
dc.contributor.authorYokus, B.
dc.contributor.authorUstundag, M.
dc.contributor.authorOrak, M.
dc.date.accessioned2024-04-24T17:38:03Z
dc.date.available2024-04-24T17:38:03Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: The aim of this study was to examine the level of myeloperoxidase (MPO) measured before specific treatment in patients presenting to the Emergency Department with acute ischemic stroke and its correlation to mortality and the severity of the stroke. PATIENTS AND METHODS: The study was carried out on 55 patients with a confirmed diagnosis of ischemic stroke, and on 44 healthy control group. Before specific intervention, serum samples were taken to measure levels of MPO. The medical records, demographic, clinical, laboratory and neuro-imaging data were noted. The National Institutes of Health Stroke Scale was used to determine the severity of the stroke. RESULTS: A total of 55 patients, of whom 32 (58.2%) were male, who had presented within 24 hours of the onset of symptoms of acute ischemic stroke were included in the study. Fifteen of these patients (27.2%), of whom five were women, died. There was a statistically significant difference in the serum MPO levels of patients who survived and those who died. When the patients were grouped as high or normal in terms of plasma MPO levels, a significant correlation was found between MPO level, cortical + subcortical stroke location and strokes with a lesion diameter of more than 4 cm. In the high MPO group, Troponin T and CRP levels were significantly higher than those of the normal MPO group. CONCLUSIONS: The level of myeloperoxidase in the serum of acute ischemic stroke patients rises and there is a correlation between myeloperoxidase level and prognosis.en_US
dc.identifier.endpage1988en_US
dc.identifier.issn1128-3602
dc.identifier.issue11en_US
dc.identifier.pmid26125258
dc.identifier.scopus2-s2.0-84942253704
dc.identifier.scopusqualityQ2
dc.identifier.startpage1983en_US
dc.identifier.urihttps://hdl.handle.net/11468/21304
dc.identifier.volume19en_US
dc.identifier.wosWOS:000357615400009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Ischemic Strokeen_US
dc.subjectMyeloperoxidaseen_US
dc.subjectInflammationen_US
dc.subjectMortalityen_US
dc.subjectAtherosclerosisen_US
dc.titleSerum myeloperoxidase levels in predicting the severity of stroke and mortality in acute ischemic stroke patientsen_US
dc.titleSerum myeloperoxidase levels in predicting the severity of stroke and mortality in acute ischemic stroke patients
dc.typeArticleen_US

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