Amniotic fluid amino acid levels in non-immune hydrops fetalis: a case-control study

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dc.contributor.authorErdemoglu, M.
dc.contributor.authorKuyumcuoglu, U.
dc.contributor.authorGuzel, A. I.
dc.contributor.authorCelik, Y.
dc.contributor.authorKale, E.
dc.date.accessioned2024-04-24T17:18:09Z
dc.date.available2024-04-24T17:18:09Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn a prospective case-control study, we compared the amniotic fluid amino acid levels in non-immune hydrops fetalis (NIHF) and normal fetuses. Eighty fetuses underwent amniocentesis for different reasons at the prenatal diagnosis unit of the Department of Obstetrics and Gynecology, Faculty of Medicine, Dicle University. Forty of these fetuses were diagnosed with NIHF. The study included 40 women each in the NIHF (mean age: 27.69 +/- 4.56 years) and control (27.52 +/- 5.49 years) groups, who had abnormal double-or triple-screening test values with normal fetuses with gestational ages of 23.26 +/- 1.98 and 23.68 +/- 1.49 weeks at the time of sample collection, respectively. Amniotic fluid amino acid concentrations (intra-assay variation: 2.26-7.85%; interassay variation: 3.45-8.22%) were measured using EZ: faast kits (EZ: faast GC/FID free (physiological) amino acid kit; Phenomenex, USA) by gas chromatography. The standard for quantitation was a mixture of free amino acids from Phenomenex. The levels of 21 amino acids were measured. The mean phosphoserine and serine levels were significantly lower in the NIHF group, while the taurine, a-aminoadipic acid (aaa), glycine, cysteine, NH(4), and arginine (Arg) levels were significantly higher compared to control. Significant risk variables for the NIHF group and odds coefficients were obtained using a binary logistic regression method. The respective odds ratios and 95% confidence intervals for the risk variables phosphoserine, taurine, aaa, Arg, and NH(4) were 3.31 (1.84-5.97), 2.45 (1.56-3.86), 1.78 (1.18-2.68), 2.18 (1.56-3.04), and 2.41 (1.66-3.49), respectively. The significant difference between NIHF and control fetuses suggests that the amniotic fluid levels of some amino acids may be useful for the diagnosis of NIHF.en_US
dc.identifier.doi10.1590/S0100-879X2011007500076
dc.identifier.endpage728en_US
dc.identifier.issn0100-879X
dc.identifier.issue7en_US
dc.identifier.pmid21833460
dc.identifier.scopus2-s2.0-79961078784
dc.identifier.scopusqualityQ1
dc.identifier.startpage725en_US
dc.identifier.urihttps://doi.org/10.1590/S0100-879X2011007500076
dc.identifier.urihttps://hdl.handle.net/11468/18640
dc.identifier.volume44en_US
dc.identifier.wosWOS:000293651700018
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAssoc Bras Divulg Cientificaen_US
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNon-Immune Hydrops Fetalisen_US
dc.subjectAmniotic Fluiden_US
dc.subjectAmino Acid Levelsen_US
dc.titleAmniotic fluid amino acid levels in non-immune hydrops fetalis: a case-control studyen_US
dc.titleAmniotic fluid amino acid levels in non-immune hydrops fetalis: a case-control study
dc.typeArticleen_US

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