Possible Association of FAS and FASLG Polymorphisms with the Risk of Idiopathic Azoospermia in Southeast Turkey

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dc.contributor.authorBalkan, Mahmut
dc.contributor.authorAtar, Murat
dc.contributor.authorErdal, Mehmet Emin
dc.contributor.authorRustemoglu, Aydin
dc.contributor.authorYildiz, Ismail
dc.contributor.authorGunesacar, Ramazan
dc.contributor.authorHatipoglu, Namik Kemal
dc.date.accessioned2024-04-24T17:08:02Z
dc.date.available2024-04-24T17:08:02Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractTo investigate the association of the genetic variants of FAS/FASLG cell death pathway genes in male infertility, we genotyped the FAS -670A/G, -1377G/A, and FASLG -124A/G single-nucleotide polymorphisms (SNPs) by real-time polymerase chain reaction in 108 infertile men with idiopathic azoospermia and in 125 proven fertile controls. The distribution of genotypes and alleles for SNPs at FAS -1377G/A and FASLG -124A/G loci were determined not to be statistically different between the case and control groups. However, the genotype frequencies of SNPs, FAS -670AA and FAS -670AG, were found to be significantly different between the case and control groups. Whereas the FAS -670AA genotype might be regarded as a higher predisposition for idiopathic azoospermia, FAS -670AG could be interpreted to mean that this genotype provides protection against idiopathic azoospermia. The study of combined genotype and haplotype frequencies has found statistically significant differences between case and control subjects for some combinations. The AA-GG binary genotype for the FAS670 and FAS1377 loci couple, in particular, may have a high degree of predisposition to idiopathic azoospermia. Our results suggest that FAS -670A/G SNP may be a genetic predisposing factor of idiopathic azoospermia among southeastern Anatolian men. Larger studies are needed to verify these findings. Furthermore, our data indicated a possible linkage between the FAS and FASLG genes and idiopathic azoospermia.en_US
dc.identifier.doi10.1089/gtmb.2013.0454
dc.identifier.endpage388en_US
dc.identifier.issn1945-0265
dc.identifier.issn1945-0257
dc.identifier.issue6en_US
dc.identifier.pmid24665877
dc.identifier.scopus2-s2.0-84901982371
dc.identifier.scopusqualityQ3
dc.identifier.startpage383en_US
dc.identifier.urihttps://doi.org/10.1089/gtmb.2013.0454
dc.identifier.urihttps://hdl.handle.net/11468/17164
dc.identifier.volume18en_US
dc.identifier.wosWOS:000337183000003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofGenetic Testing and Molecular Biomarkers
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titlePossible Association of FAS and FASLG Polymorphisms with the Risk of Idiopathic Azoospermia in Southeast Turkeyen_US
dc.titlePossible Association of FAS and FASLG Polymorphisms with the Risk of Idiopathic Azoospermia in Southeast Turkey
dc.typeArticleen_US

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