DNA binding and cleavage activity of three new copper (II) complexes of chiral N-salicyl-?-amino alcohol schiff bases

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dc.authorid0000-0002-2431-8027en_US
dc.authorid0000-0002-8571-5552en_US
dc.authorid0000-0001-5301-2628en_US
dc.authorid0000-0002-3774-2652en_US
dc.contributor.authorTunç, Turgay
dc.contributor.authorDemirel, Nadir
dc.contributor.authorEmir, Mahmut
dc.contributor.authorGünel, Aslıhan
dc.contributor.authorÇolak, Mehmet
dc.contributor.authorKaracan, Nurcan
dc.date.accessioned2024-02-29T11:41:33Z
dc.date.available2024-02-29T11:41:33Z
dc.date.issued2018en_US
dc.departmentDicle Üniversitesi, Fen Fakültesi, Kimya Bölümüen_US
dc.description.abstractThree new copper(II) complexes (1-3) with general formula [Cu(HL)CH 3 COO] of N-salicyl-β-amino alcohol Schiff bases containing, (S)-(+)-phenyl glycinol, (1S, 2R)-2-amino-1, 2-diphenylethanol and 1, 1, 3-triphenyl-(R)-(+)-2-amino propanol, were synthesized. Their structures were characterized by FTIR, LCMS, magnetic moment, molar conductance and elemental analysis data. DFT calculations proposed distorted square planar geometries for the complexes. The calculated IR spectra are in good agreement with the experimental IR spectra, confirming the proposed structures. Their interactions with calf thymus DNA were investigated and their binding constants K b were found. Gel electrophoresis reveals that all complexes display significant nuclease activity against supercoiled pentry/d-topo plasmid DNA.en_US
dc.identifier.citationTunç, T., Demirel, N., Emir, M., Aslıhan, G., Çolak, M. ve Sever, N. (2018). DNA binding and cleavage activity of three new copper (II) complexes of chiral N-salicyl-β-amino alcohol schiff bases. Journal of the Mexican Chemical Society, 62(3), 51-66.en_US
dc.identifier.doi10.29356/jmcs.v62i3.424
dc.identifier.endpage66en_US
dc.identifier.issn1870-249X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85064208986
dc.identifier.scopusqualityQ3
dc.identifier.startpage51en_US
dc.identifier.urihttps://www.jmcs.org.mx/index.php/jmcs/article/view/424/490
dc.identifier.urihttps://hdl.handle.net/11468/13433
dc.identifier.volume62en_US
dc.identifier.wosWOS:000496746700006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÇolak, Mehmet
dc.language.isoenen_US
dc.publisherSociedad Quimica de Mexico A.C.en_US
dc.relation.ispartofJournal of the Mexican Chemical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCopper (II) complexesen_US
dc.subjectDFT calculationsen_US
dc.subjectDNA bindingen_US
dc.subjectDNA cleavageen_US
dc.subjectSchiff base complexesen_US
dc.titleDNA binding and cleavage activity of three new copper (II) complexes of chiral N-salicyl-?-amino alcohol schiff basesen_US
dc.titleDNA binding and cleavage activity of three new copper (II) complexes of chiral N-salicyl-?-amino alcohol schiff bases
dc.typeArticleen_US

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