DNA binding and cleavage activity of three new copper (II) complexes of chiral N-salicyl-?-amino alcohol schiff bases
Yükleniyor...
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sociedad Quimica de Mexico A.C.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Three new copper(II) complexes (1-3) with general formula [Cu(HL)CH 3 COO] of N-salicyl-β-amino alcohol Schiff bases containing, (S)-(+)-phenyl glycinol, (1S, 2R)-2-amino-1, 2-diphenylethanol and 1, 1, 3-triphenyl-(R)-(+)-2-amino propanol, were synthesized. Their structures were characterized by FTIR, LCMS, magnetic moment, molar conductance and elemental analysis data. DFT calculations proposed distorted square planar geometries for the complexes. The calculated IR spectra are in good agreement with the experimental IR spectra, confirming the proposed structures. Their interactions with calf thymus DNA were investigated and their binding constants K b were found. Gel electrophoresis reveals that all complexes display significant nuclease activity against supercoiled pentry/d-topo plasmid DNA.
Açıklama
Anahtar Kelimeler
Copper (II) complexes, DFT calculations, DNA binding, DNA cleavage, Schiff base complexes
Kaynak
Journal of the Mexican Chemical Society
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
62
Sayı
3
Künye
Tunç, T., Demirel, N., Emir, M., Aslıhan, G., Çolak, M. ve Sever, N. (2018). DNA binding and cleavage activity of three new copper (II) complexes of chiral N-salicyl-β-amino alcohol schiff bases. Journal of the Mexican Chemical Society, 62(3), 51-66.
