DNA binding and cleavage activity of three new copper (II) complexes of chiral N-salicyl-?-amino alcohol schiff bases

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Küçük Resim

Tarih

2018

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Sociedad Quimica de Mexico A.C.

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Three new copper(II) complexes (1-3) with general formula [Cu(HL)CH 3 COO] of N-salicyl-β-amino alcohol Schiff bases containing, (S)-(+)-phenyl glycinol, (1S, 2R)-2-amino-1, 2-diphenylethanol and 1, 1, 3-triphenyl-(R)-(+)-2-amino propanol, were synthesized. Their structures were characterized by FTIR, LCMS, magnetic moment, molar conductance and elemental analysis data. DFT calculations proposed distorted square planar geometries for the complexes. The calculated IR spectra are in good agreement with the experimental IR spectra, confirming the proposed structures. Their interactions with calf thymus DNA were investigated and their binding constants K b were found. Gel electrophoresis reveals that all complexes display significant nuclease activity against supercoiled pentry/d-topo plasmid DNA.

Açıklama

Anahtar Kelimeler

Copper (II) complexes, DFT calculations, DNA binding, DNA cleavage, Schiff base complexes

Kaynak

Journal of the Mexican Chemical Society

WoS Q Değeri

Q4

Scopus Q Değeri

Q3

Cilt

62

Sayı

3

Künye

Tunç, T., Demirel, N., Emir, M., Aslıhan, G., Çolak, M. ve Sever, N. (2018). DNA binding and cleavage activity of three new copper (II) complexes of chiral N-salicyl-β-amino alcohol schiff bases. Journal of the Mexican Chemical Society, 62(3), 51-66.